{"id":"W4205494230","doi":"10.1093/brain/awab472","title":"The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Economic and Social Research Council; Medical Research Council; Ministero della Salute; Fonds Wetenschappelijk Onderzoek; King's College London; Vlaamse regering; Motor Neurone Disease Association; KU Leuven; Ministero dell’Istruzione, dell’Università e della Ricerca; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; National Health and Medical Research Council; King’s College London","keywords":"Amyotrophic lateral sclerosis; Genetic testing; Medicine; Incidence (geometry); Psychology; Disease; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005949758,0.0005320262,0.0009367821,0.001127632,0.002247994,0.002436587,0.001070731,0.007306036,0.01076946],"category_scores_gemma":[0.02696874,0.0004432233,0.0007677492,0.0004349648,0.001258872,0.005567271,0.001846382,0.007519409,0.00458265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000989239,"about_ca_system_score_gemma":0.004229189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005886909,"about_ca_topic_score_gemma":0.007202078,"domain_scores_codex":[0.9964743,0.001331329,0.0003571757,0.0002934224,0.0008565076,0.0006872885],"domain_scores_gemma":[0.9845746,0.005588846,0.0006832884,0.0007176019,0.003878901,0.004556781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009554118,0.001328486,0.125526,0.0007028666,0.0001647034,0.02596131,0.003124358,0.0009340621,0.006128735,0.005399349,0.3605377,0.469237],"study_design_scores_gemma":[0.0005052708,0.002336013,0.1700005,0.007905019,0.0003572808,0.09121464,0.01450781,0.001921303,0.006209635,0.08676005,0.6176255,0.0006569235],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.07253598,0.02260252,0.01454925,0.7980481,0.01460159,0.0005001733,0.0003779615,0.001217403,0.07556695],"genre_scores_gemma":[0.5825702,0.02955859,0.05484809,0.2810055,0.02560863,0.000797941,0.0007099865,0.0004535903,0.02444732],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01076946,"threshold_uncertainty_score":0.03602743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04521810164811845,"score_gpt":0.2685626476247358,"score_spread":0.2233445459766173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}