{"id":"W4205496667","doi":"10.1200/po.21.00303","title":"Sustained Response to the Mitogen-Activated Extracellular Kinase Inhibitor Trametinib in a Spindle Cell Sarcoma Harboring a QKI-RAF1 Gene Fusion","year":2022,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Trametinib; Fusion gene; Kinase; Extracellular; Fusion protein; Sarcoma; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008824139,0.0001471238,0.0002564371,0.0001245633,0.0001537471,0.0002116873,0.0001515892,0.0003714325,0.0007467093],"category_scores_gemma":[0.0001604254,0.00007889466,0.0002316798,0.0001222482,0.0001315707,0.0001173265,0.00008449855,0.0006247679,0.000177676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003047896,"about_ca_system_score_gemma":0.0001990185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001928281,"about_ca_topic_score_gemma":0.002281598,"domain_scores_codex":[0.9999278,0.000007114862,0.000005943493,0.00001229364,0.0000140281,0.00003276059],"domain_scores_gemma":[0.9999326,0.00002118552,0.00001149745,0.000006361376,0.000005660504,0.00002277106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.001970377,0.0002878786,0.001081719,0.00002362907,0.00001788584,0.003024461,0.00004029914,0.0004060764,0.9888262,0.00008358988,0.0003048207,0.003933218],"study_design_scores_gemma":[0.0003754433,0.008398538,0.04547517,0.00000619661,0.0001060484,0.01279259,0.0001880012,0.01063103,0.9180861,0.0001488275,0.003763346,0.00002887486],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998752,0.0002019862,0.0002054019,0.000135103,0.00002723767,0.00001175493,0.0001505541,0.00002144906,0.0004944237],"genre_scores_gemma":[0.9990218,0.00007875502,0.0001434198,0.00003181569,0.000004518203,0.000005740496,0.0002010831,0.000002420658,0.0005104637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928281,"threshold_uncertainty_score":0.003834069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470780351789838,"score_gpt":0.2669338896149859,"score_spread":0.2522260860970875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}