{"id":"W4205501172","doi":"10.1002/alz.12543","title":"Increased RyR2 open probability induces neuronal hyperactivity and memory loss with or without Alzheimer's disease–causing gene mutations","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Ryanodine receptor 2; Mutation; Premovement neuronal activity; Neuroscience; Mutant; Ryanodine receptor; Biology; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002016073,0.0005261009,0.0004451367,0.0004152162,0.0001911872,0.0002619078,0.0002862478,0.0004765488,0.00170129],"category_scores_gemma":[0.0001470872,0.0002007138,0.000406514,0.0001751854,0.000434398,0.0002676606,0.0003336205,0.0008326922,0.000206767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052054,"about_ca_system_score_gemma":0.0002272606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007280559,"about_ca_topic_score_gemma":0.001325003,"domain_scores_codex":[0.9997448,0.00003651785,0.00004051428,0.00005912613,0.00006213525,0.00005689369],"domain_scores_gemma":[0.9998437,0.000025554,0.00005102796,0.00001749002,0.000009164039,0.00005300566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003070294,0.0001685868,0.0004169978,0.00003926264,0.00001866606,0.0002644604,0.00002240895,0.00004258352,0.9978316,0.00006667268,0.00006878608,0.0007529456],"study_design_scores_gemma":[0.0001631441,0.002830985,0.0270255,0.00002348227,0.0001218116,0.002256325,0.00009271014,0.001096104,0.965089,0.0001185463,0.001166624,0.00001571191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983809,0.0003019853,0.0004221818,0.00004581748,0.00002088146,0.00001833154,0.0001518108,0.00004438267,0.0006137989],"genre_scores_gemma":[0.9978537,0.0002439563,0.0006145044,0.00005408694,0.00001372359,0.00005673595,0.0002489297,0.00001508874,0.0008992698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170129,"threshold_uncertainty_score":0.005691409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06397252712062318,"score_gpt":0.3324776576666044,"score_spread":0.2685051305459812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}