{"id":"W4205505245","doi":"10.1101/2022.01.07.475305","title":"A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Centre for Global Health Research; Dalhousie University; Montreal Heart Institute; Université de Montréal; Université Laval","funders":"National Key Research and Development Program of China; Korea National Institute of Health; Cancer Council Tasmania; Cancer Council Victoria; Economic and Social Research Council; Forsknings- og Innovationsstyrelsen; Perelman School of Medicine, University of Pennsylvania; Fundación Marqués de Valdecilla; Biosense Webster; Diabetesforeningen; Xarxa de Bancs de Tumors de Catalunya; National University of Singapore; Skånes universitetssjukhus; TrygFonden; Department of Health, Government of Western Australia; Menzies Institute for Medical Research; Center for Translational Molecular Medicine; Academia Sinica; Deutsche Krebshilfe; Wageningen University and Research; Helsefonden; Medizinische Universität Wien; Novo Nordisk; Universitätsklinikum Regensburg; Movember Foundation; Fondation ARC pour la Recherche sur le Cancer; Government of Western Australia; Karolinska Institutet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Research Foundation Singapore; Regione Campania; Lundbeckfonden; Ministero della Salute; Fonds Wetenschappelijk Onderzoek; Universität Wien; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; European Commission; Nederlandse Zuivel Organisatie; Else Kröner-Fresenius-Stiftung; Ministerie van Volksgezondheid, Welzijn en Sport; Institut National Du Cancer; Nierstichting; Translational Genomics Research Institute; Deutsche Herzstiftung; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Safe Work Australia; Cancer Research Institute; NorthShore University HealthSystem; Region Hovedstaden; National Medical Research Council; Stockholms Läns Landsting; KU Leuven; National Science Council; National Research Foundation of Korea; Canadian Cancer Society Research Institute; Kompetenznetz Vorhofflimmern; National Natural Science Foundation of China; Edith Cowan University; Sundhed og Sygdom, Det Frie Forskningsråd; Murdoch University; Children's Hospital of Philadelphia; Stiftelsen för Strategisk Forskning; Rijksuniversiteit Groningen; University of Washington; Curtin University of Technology; Council of Scientific and Industrial Research, India; Broad Institute; Australian Government; Vlaamse regering; National Research Foundation; Medical Research Council; Hjärt-Lungfonden; Cancer Australia; Ministerie van Economische Zaken, Landbouw en Innovatie; Diabetestutkimussäätiö; Heinz Nixdorf Stiftung; Strategiske Forskningsråd; Government of Canada; University of Notre Dame Australia; Departament d'Universitats, Recerca i Societat de la Informació; European Federation of Pharmaceutical Industries and Associations; H. Lundbeck A/S; Rosetrees Trust; Cotswold Foundation; Finska Läkaresällskapet; Ministeriet Sundhed Forebyggelse; Danish Agency for Science and Higher Education; Genome Canada; Raine Medical Research Foundation; China-Japan Friendship Hospital; Deutsche Forschungsgemeinschaft; University of Exeter; Instituto de Salud Carlos III; National Institute for Nutrition and Health; National Cancer Research Institute; National University Health System; University of Pennsylvania; Fondation de France; Cancer Council Queensland; Sanofi; Universitair Medisch Centrum Groningen; Deutsches Zentrum für Herz-Kreislaufforschung; Pancreatic Cancer UK; Háskóli Íslands; Women and Infants Research Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Boettcher Foundation; Swedish Cancer Foundation; Hjerteforeningen; University of Notre Dame; Taichung Veterans General Hospital; Fondation du cancer du sein du Québec; Helsingin ja Uudenmaan Sairaanhoitopiiri; Vrije Universiteit Amsterdam; Victor Chang Cardiac Research Institute; Australian Research Council; Velux Stiftung","keywords":"Single-nucleotide polymorphism; Linkage disequilibrium; Genome-wide association study; Genetics; Biology; Heritability; Genetic association; Missing heritability problem; Human genome; SNP; Gene; Genome; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005795421,0.0002278405,0.0005137657,0.001514122,0.0005280655,0.0006006987,0.0002833577,0.0003872273,0.005826452],"category_scores_gemma":[0.002040967,0.0002903936,0.0005823117,0.001917303,0.000333152,0.000242691,0.001161515,0.0004809402,0.0007274748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885638,"about_ca_system_score_gemma":0.0003671994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005172751,"about_ca_topic_score_gemma":0.004522125,"domain_scores_codex":[0.999587,0.00006617522,0.00002006142,0.00018739,0.00007759604,0.00006182413],"domain_scores_gemma":[0.9989594,0.0005885134,0.000132063,0.0001201862,0.00008742567,0.0001123563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001781885,0.000164382,0.71868,0.0007760891,0.002383185,0.002354613,0.00145659,0.01251441,0.1565861,0.005656746,0.00835631,0.08928964],"study_design_scores_gemma":[0.00005862437,0.0001069722,0.9763814,0.00004254662,0.0002645401,0.0007287781,0.0002370212,0.005984665,0.003887417,0.004658907,0.007619926,0.00002932165],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675583,0.001255521,0.01409473,0.000364962,0.00002128957,0.00001655152,0.01433009,0.0003282331,0.002030088],"genre_scores_gemma":[0.9805216,0.0003516296,0.004699381,0.0001550201,0.00002463675,0.00002134917,0.01332042,0.00004519748,0.0008607141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005826452,"threshold_uncertainty_score":0.01949137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698630402371028,"score_gpt":0.2368082305129876,"score_spread":0.2198219264892773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}