{"id":"W4205505245","doi":"10.1101/2022.01.07.475305","title":"A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Centre for Global Health Research; Dalhousie University; Montreal Heart Institute; Université de Montréal; Université Laval","funders":"National Key Research and Development Program of China; Korea National Institute of Health; Cancer Council Tasmania; Cancer Council Victoria; Economic and Social Research Council; Forsknings- og Innovationsstyrelsen; Perelman School of Medicine, University of Pennsylvania; Fundación Marqués de Valdecilla; Biosense Webster; Diabetesforeningen; Xarxa de Bancs de Tumors de Catalunya; National University of Singapore; Skånes universitetssjukhus; TrygFonden; Department of Health, Government of Western Australia; Menzies Institute for Medical Research; Center for Translational Molecular Medicine; Academia Sinica; Deutsche Krebshilfe; Wageningen University and Research; Helsefonden; Medizinische Universität Wien; Novo Nordisk; Universitätsklinikum Regensburg; Movember Foundation; Fondation ARC pour la Recherche sur le Cancer; Government of Western Australia; Karolinska Institutet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Research Foundation Singapore; Regione Campania; Lundbeckfonden; Ministero della Salute; Fonds Wetenschappelijk Onderzoek; Universität Wien; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; European Commission; Nederlandse Zuivel Organisatie; Else Kröner-Fresenius-Stiftung; Ministerie van Volksgezondheid, Welzijn en Sport; Institut National Du Cancer; Nierstichting; Translational Genomics Research Institute; Deutsche Herzstiftung; Ministerio de Ciencia e Innovación; Generalitat de Catalunya; Safe Work Australia; Cancer Research Institute; NorthShore University HealthSystem; Region Hovedstaden; National Medical Research Council; Stockholms Läns Landsting; KU Leuven; National Science Council; National Research Foundation of Korea; Canadian Cancer Society Research Institute; Kompetenznetz Vorhofflimmern; National Natural Science Foundation of China; Edith Cowan University; Sundhed og Sygdom, Det Frie Forskningsråd; Murdoch University; Children's Hospital of Philadelphia; Stiftelsen för Strategisk Forskning; Rijksuniversiteit Groningen; University of Washington; Curtin University of Technology; Council of Scientific and Industrial Research, India; Broad Institute; Australian Government; Vlaamse regering; National Research Foundation; Medical Research Council; Hjärt-Lungfonden; Cancer Australia; Ministerie van Economische Zaken, Landbouw en Innovatie; Diabetestutkimussäätiö; Heinz Nixdorf Stiftung; Strategiske Forskningsråd; Government of Canada; University of Notre Dame Australia; Departament d'Universitats, Recerca i Societat de la Informació; European Federation of Pharmaceutical Industries and Associations; H. Lundbeck A/S; Rosetrees Trust; Cotswold Foundation; Finska Läkaresällskapet; Ministeriet Sundhed Forebyggelse; Danish Agency for Science and Higher Education; Genome Canada; Raine Medical Research Foundation; China-Japan Friendship Hospital; Deutsche Forschungsgemeinschaft; University of Exeter; Instituto de Salud Carlos III; National Institute for Nutrition and Health; National Cancer Research Institute; National University Health System; University of Pennsylvania; Fondation de France; Cancer Council Queensland; Sanofi; Universitair Medisch Centrum Groningen; Deutsches Zentrum für Herz-Kreislaufforschung; Pancreatic Cancer UK; Háskóli Íslands; Women and Infants Research Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Boettcher Foundation; Swedish Cancer Foundation; Hjerteforeningen; University of Notre Dame; Taichung Veterans General Hospital; Fondation du cancer du sein du Québec; Helsingin ja Uudenmaan Sairaanhoitopiiri; Vrije Universiteit Amsterdam; Victor Chang Cardiac Research Institute; Australian Research Council; Velux Stiftung","keywords":"Single-nucleotide polymorphism; Linkage disequilibrium; Genome-wide association study; Genetics; Biology; Heritability; Genetic association; Missing heritability problem; Human genome; SNP; Gene; Genome; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005137976,0.0004149775,0.000825008,0.0001454102,0.0001683706,0.00002354648,0.0005733985,0.0006618041,0.0001005453],"category_scores_gemma":[0.0002263582,0.0004202123,0.000152865,0.0002719228,0.000243426,0.000005381784,0.0007090314,0.0004018453,0.000002185048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008863249,"about_ca_system_score_gemma":0.0004126895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004656173,"about_ca_topic_score_gemma":0.00004953212,"domain_scores_codex":[0.9972492,0.0005328405,0.0007589792,0.0007580097,0.0003195169,0.0003814788],"domain_scores_gemma":[0.9969479,0.00007395131,0.001478376,0.0009680369,0.0004208287,0.000110933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004222424,0.0002474838,0.4985246,0.00006854908,0.0008359957,0.000008594337,0.00002093989,0.0006541568,0.4989405,0.00002073871,0.0006351107,0.000001134798],"study_design_scores_gemma":[0.0007624751,0.0003242948,0.911209,0.000138217,0.0002617977,8.559169e-9,0.00001558247,0.00004663956,0.08614005,0.00001159954,0.0006622832,0.0004280014],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944696,0.001726475,0.000172426,0.00005589819,0.0003178344,0.0004548869,0.002765598,0.00003083751,0.000006464974],"genre_scores_gemma":[0.9965118,0.0002504024,0.002836847,0.00006320228,0.0001163038,0.00008616236,0.00005958402,0.00006573174,0.0000100152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4128004,"threshold_uncertainty_score":0.9998249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698630402371028,"score_gpt":0.2368082305129876,"score_spread":0.2198219264892773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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