{"id":"W4205510598","doi":"10.1161/circulationaha.121.056892","title":"Circulating Metabolome and White Matter Hyperintensities in Women and Men","year":2022,"lang":"en","type":"review","venue":"Circulation","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cégep de Chicoutimi; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto; SickKids Foundation; Hospital for Sick Children; Université du Québec à Chicoutimi","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; Medical Research Council; Erasmus Medisch Centrum; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; ZonMw; European Commission; Age UK; Dementias Platform UK; British Heart Foundation; University College London; Canadian Institutes of Health Research; National Institute for Health and Care Research; Hospital for Sick Children; Heart and Stroke Foundation of Canada","keywords":"Medicine; Hyperintensity; Internal medicine; Metabolome; Linear regression; Population; False discovery rate; Cardiology; Magnetic resonance imaging; Statistics; Metabolite; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00401293,0.000994313,0.00249614,0.001204567,0.0003425092,0.001362044,0.0006188918,0.0009443689,0.00167461],"category_scores_gemma":[0.007649417,0.0005721563,0.008180428,0.002532225,0.0004766338,0.0005363513,0.000714256,0.0006753731,0.0001845926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004248502,"about_ca_system_score_gemma":0.0004282115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003121499,"about_ca_topic_score_gemma":0.002761504,"domain_scores_codex":[0.9984432,0.0005883922,0.0001708005,0.0005546712,0.0001347228,0.0001082484],"domain_scores_gemma":[0.9961415,0.002267784,0.0009177842,0.0004055813,0.0001644237,0.000102828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"systematic_review","study_design_scores_codex":[0.009495455,0.0000640718,0.7749556,0.006038857,0.1759124,0.0004240115,0.0001796741,0.001821619,0.00157411,0.0004117084,0.001278213,0.02784431],"study_design_scores_gemma":[0.0008343768,0.001074996,0.7716553,0.001524859,0.2126767,0.0008505901,0.0002065799,0.002378958,0.001180887,0.001800806,0.005748867,0.00006703298],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5495986,0.4421266,0.002485504,0.001008329,0.0003092779,0.00004772071,0.002980178,0.0000874153,0.001356323],"genre_scores_gemma":[0.9611189,0.0358758,0.0009041533,0.0004363789,0.0003301853,0.00006953062,0.0009762555,0.00002483298,0.0002639299],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00401293,"threshold_uncertainty_score":0.02122265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411356768547464,"score_gpt":0.2672208662480185,"score_spread":0.2431072985625439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}