{"id":"W4205519374","doi":"10.1016/j.bpc.2021.106741","title":"Dimethyl sulfoxide (DMSO) is a stabilizing co-solvent for G-quadruplex DNA","year":2022,"lang":"en","type":"article","venue":"Biophysical Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Dimethyl sulfoxide; Urea; Solvent; Intramolecular force; Sulfoxide; Inorganic chemistry; Crystallography; Medicinal chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001476859,0.0003041602,0.0002732293,0.00001191337,0.0003100876,0.00002992715,0.0005012765,0.0001587132,0.0004694896],"category_scores_gemma":[0.00007082681,0.0003337447,0.0003826369,0.0001165661,0.0001418718,0.000004421016,0.000380203,0.0002352803,0.00001151762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007522305,"about_ca_system_score_gemma":0.0001201713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005556141,"about_ca_topic_score_gemma":1.522976e-7,"domain_scores_codex":[0.9981183,0.00002252807,0.0003005339,0.0007446969,0.000317012,0.0004969169],"domain_scores_gemma":[0.9989195,0.00003437356,0.0001352763,0.0006521258,0.00006515629,0.0001935981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002000521,0.0002807906,0.0001175931,0.0001264491,0.00007307434,0.000004357125,0.00003829941,0.00001266002,0.9826207,0.00001293018,0.01613303,0.0003800512],"study_design_scores_gemma":[0.0006822657,0.0001197157,0.00003737233,0.000005468712,0.00003009058,0.00001303289,0.0002157043,0.00009597015,0.825355,0.00008449118,0.173003,0.0003579264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960055,0.0002245575,0.0002015886,0.0003049567,0.00009706844,0.0002119432,0.0005050187,0.00004907605,0.002400236],"genre_scores_gemma":[0.9932935,0.00001789137,0.0003351327,0.0006042004,0.000723659,0.0002770137,0.0008304349,0.00006688177,0.003851252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1572657,"threshold_uncertainty_score":0.9999115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230611169934047,"score_gpt":0.262926291996904,"score_spread":0.2506201802975636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}