{"id":"W4205522471","doi":"10.1016/j.jtct.2022.01.013","title":"Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation","year":2022,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Manitoba; CancerCare Manitoba","funders":"Swedish Orphan Biovitrum; Omeros Corporation; Jazz Pharmaceuticals; Sanofi","keywords":"Busulfan; Conditioning regimen; Young adult; Hepatic veno-occlusive disease; Regimen; Hematopoietic stem cell transplantation; Transplantation; Dosing; Hematopoietic cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000442885,0.000214369,0.0004106901,0.000574376,0.0001980567,0.0003814666,0.0001848089,0.0003188426,0.0009489287],"category_scores_gemma":[0.001910696,0.0002634462,0.0004153502,0.0007672478,0.0002141516,0.0003469723,0.0002976598,0.0005932488,0.0001039103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003448463,"about_ca_system_score_gemma":0.0004075576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003968308,"about_ca_topic_score_gemma":0.004661599,"domain_scores_codex":[0.9996004,0.00006664096,0.00007287374,0.00009281504,0.00008851778,0.00007880574],"domain_scores_gemma":[0.997992,0.0003624102,0.00125027,0.00006841426,0.0001098298,0.0002171306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005381269,0.000007434359,0.9993361,0.000006076549,0.00001672468,0.00006399441,0.00002010745,0.00002643616,0.0001026585,0.000007997199,0.00002201909,0.0003365687],"study_design_scores_gemma":[0.000003702895,0.0001009484,0.9989331,0.000006766222,0.0000247298,0.0004772207,0.0001014223,0.0001214599,0.00007806572,0.000008547566,0.000141373,0.000002594816],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991136,0.0003852708,0.00006023653,0.00001708942,0.000002537027,0.000004749103,0.0002733834,0.000001997262,0.0001411277],"genre_scores_gemma":[0.9993461,0.0002069504,0.00007838004,0.00001366642,0.000006284006,0.000006474721,0.0002965452,0.000001377441,0.00004414224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003968308,"threshold_uncertainty_score":0.007890403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007827591743464946,"score_gpt":0.2152293106511451,"score_spread":0.2074017189076802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}