{"id":"W4205558325","doi":"10.1101/2022.01.13.476264","title":"Multifunctional properties of Nej1 <sup>XLF</sup> C-terminus promote end-joining and impact DNA double-strand break repair pathway choice","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; International Microbiome Centre, University of Calgary; Cumming School of Medicine, University of Calgary","keywords":"Non-homologous end joining; DNA ligase; Homologous recombination; Ligation; DNA; Nuclease; DNA repair; Biology; Mutant; Cell biology; Genetics; Chemistry; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279507,0.0003041191,0.000167764,0.0001425261,0.0001581182,0.0002511023,0.0002114109,0.0002483944,0.004202659],"category_scores_gemma":[0.0001017445,0.0001081758,0.0001957857,0.00009836993,0.0001766486,0.0001589471,0.0001541279,0.0005331493,0.000880389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000290962,"about_ca_system_score_gemma":0.0001108285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005621931,"about_ca_topic_score_gemma":0.000698724,"domain_scores_codex":[0.9998916,0.00001468908,0.00001499446,0.00002193627,0.00003218871,0.00002455493],"domain_scores_gemma":[0.9998127,0.00003870379,0.0000578806,0.0000177907,0.0000148296,0.00005811872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006498062,0.00001018171,0.00008441643,0.00002085319,0.000002283675,0.00002020717,0.000003509474,0.00003207146,0.9994012,0.0000481066,0.00003233046,0.0002799214],"study_design_scores_gemma":[0.00001681175,0.00007868053,0.005393594,0.000007127346,0.00000796217,0.0002511003,0.00001447513,0.000660652,0.990222,0.00002583949,0.003316953,0.000004866796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944681,0.001034908,0.00172965,0.0001067653,0.00003226404,0.00001657386,0.001101536,0.00006942028,0.00144069],"genre_scores_gemma":[0.9933395,0.000266683,0.001761843,0.00005494777,0.000008185036,0.00001930604,0.001398484,0.00004899098,0.003101988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004202659,"threshold_uncertainty_score":0.01405931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01638993015419694,"score_gpt":0.2248939652096709,"score_spread":0.2085040350554739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}