{"id":"W4205575843","doi":"10.1016/j.ijrobp.2021.12.160","title":"Nonrandomized Comparison of Efficacy and Side Effects of Bicalutamide Compared With Luteinizing Hormone-Releasing Hormone (LHRH) Analogs in Combination With Radiation Therapy in the CHHiP Trial","year":2022,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Royal Marsden NHS Foundation Trust; Department of Health and Social Care; National Institute for Health and Care Research; Queen's University Belfast; Cancer Research UK; Accuray; Varian Medical Systems; AstraZeneca; American Society of Clinical Oncology; Sanofi; Cilag; Astellas Pharma; Elekta","keywords":"Medicine; Bicalutamide; Prostate cancer; Clinical endpoint; Internal medicine; Luteinizing hormone; Hazard ratio; Oncology; Urology; Triptorelin; Randomized controlled trial; Gynecology; Confidence interval; Cancer; Hormone; Androgen receptor; Gonadotropin-releasing hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006857625,0.001191468,0.003008938,0.0004828009,0.000354385,0.0009840422,0.001232238,0.00146864,0.003741506],"category_scores_gemma":[0.006858336,0.0006365209,0.002243341,0.0004940505,0.001728374,0.0008469345,0.0006466968,0.001797167,0.0005684724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008055887,"about_ca_system_score_gemma":0.001139587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004860654,"about_ca_topic_score_gemma":0.0009148921,"domain_scores_codex":[0.990122,0.008338974,0.0003868713,0.0004819497,0.0003208849,0.0003491699],"domain_scores_gemma":[0.994366,0.002467237,0.00138449,0.0009416509,0.0002313926,0.0006091482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9921659,0.002732667,0.0009635398,0.00009562224,0.0008059576,0.00001204701,0.0000202705,0.0001452358,0.0005150607,0.00006066318,0.00009570418,0.002387331],"study_design_scores_gemma":[0.8376381,0.1546863,0.004839654,0.00002129526,0.000871564,0.00002883192,0.00003040208,0.0007425754,0.0005689523,0.0002707074,0.0002855155,0.00001613919],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951571,0.001137108,0.0005254268,0.0001562508,0.0001907496,0.001901709,0.0002956112,0.00003208583,0.0006040077],"genre_scores_gemma":[0.9953447,0.0003757679,0.0006251705,0.0002207725,0.0002212809,0.00217158,0.0003134538,0.00001068673,0.0007165674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006857625,"threshold_uncertainty_score":0.03626698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02338143598296769,"score_gpt":0.3298929596445748,"score_spread":0.3065115236616071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}