{"id":"W4205606019","doi":"10.1158/2326-6074.tumimm21-p038","title":"Abstract P038: Identification and functional evaluation of monoclonal antibodies specifically targeting human Carbonic Anhydrase IX","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; National Research Council Canada","funders":"","keywords":"Tumor hypoxia; Monoclonal antibody; Cancer research; Hypoxia (environmental); Carbonic anhydrase; Biology; Antibody; Chemistry; Biochemistry; Radiation therapy; Enzyme; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003782291,0.0007567591,0.000234772,0.0003805473,0.000155601,0.0002594438,0.0004552896,0.0006662729,0.001292986],"category_scores_gemma":[0.0002836172,0.0001845683,0.0003733556,0.0002075632,0.0001464939,0.0001808068,0.0001748687,0.0005993156,0.0004565317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005196009,"about_ca_system_score_gemma":0.0001976283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009126537,"about_ca_topic_score_gemma":0.0006827029,"domain_scores_codex":[0.9996948,0.00005884483,0.00002735446,0.00006058969,0.00006449523,0.0000939239],"domain_scores_gemma":[0.9998546,0.0000330591,0.00002902807,0.0000108235,0.00003709803,0.00003538116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001552923,0.000134676,0.0001830638,0.00003321132,0.000008393211,0.00004089521,0.000007839241,0.0001609574,0.9970654,0.00005066691,0.00009417902,0.002065434],"study_design_scores_gemma":[0.0001491213,0.002945863,0.004025957,0.00001189891,0.00007251628,0.0005166272,0.00001536485,0.002285591,0.985961,0.00004718391,0.003962259,0.000006609571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879785,0.002363979,0.006176404,0.0001740772,0.00005346196,0.0002674192,0.0005191794,0.0001289336,0.002338065],"genre_scores_gemma":[0.9882655,0.001163873,0.005844472,0.000144511,0.00003379332,0.0001985642,0.002101903,0.00002964216,0.002217712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292986,"threshold_uncertainty_score":0.004325449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09562450883257141,"score_gpt":0.3860122914572778,"score_spread":0.2903877826247064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}