{"id":"W4205629395","doi":"10.15252/embj.2020106825","title":"Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes","year":2022,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Université de Montréal; Institute for Research in Immunology and Cancer; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Endocrinology; Internal medicine; Phosphorylation; Retinoblastoma protein; Cell cycle; Knockout mouse; Cell biology; Apoptosis; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003456154,0.001567361,0.0008283912,0.001973389,0.0004500212,0.001024682,0.0006530253,0.001460557,0.006963548],"category_scores_gemma":[0.0003075354,0.0009368142,0.0006212543,0.0006664403,0.001078315,0.0007444176,0.0005825381,0.002372778,0.001830575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003623108,"about_ca_system_score_gemma":0.0003432439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009039169,"about_ca_topic_score_gemma":0.001415817,"domain_scores_codex":[0.9995384,0.00003943195,0.00006095702,0.0001610055,0.0001141097,0.00008595669],"domain_scores_gemma":[0.9989076,0.00009275682,0.0005083219,0.00007783179,0.000055189,0.0003583523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006392889,0.00005783042,0.0002941749,0.00005856861,0.00002859817,0.0003577894,0.00002782806,0.00006716794,0.9967781,0.0003024537,0.0001735082,0.00121475],"study_design_scores_gemma":[0.0002927275,0.0006140636,0.01939398,0.00006100206,0.000193164,0.004692108,0.0002578915,0.001273968,0.9634057,0.0008255622,0.008931897,0.00005780507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703181,0.003890557,0.01177199,0.001038298,0.0004511139,0.00006453979,0.006530433,0.001998897,0.00393605],"genre_scores_gemma":[0.9664586,0.002992177,0.008109243,0.0004285123,0.00009668519,0.0001366515,0.003002164,0.001011443,0.01776455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006963548,"threshold_uncertainty_score":0.0232954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009376364893241548,"score_gpt":0.2284729856535686,"score_spread":0.2190966207603271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}