{"id":"W4205646931","doi":"10.1186/s42466-021-00166-5","title":"Neurological management and work-up of neurotoxicity associated with CAR T cell therapy","year":2022,"lang":"en","type":"article","venue":"Neurological Research and Practice","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Neurotoxicity; Cytokine release syndrome; Neurological examination; Post-concussion syndrome; Internal medicine; Oncology; Surgery; Concussion; Chimeric antigen receptor; Poison control; Immunotherapy; Toxicity; Emergency medicine; Injury prevention","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003857857,0.0001830824,0.0003583006,0.0002087328,0.0004171677,0.00005950884,0.0002493136,0.0001047033,0.001519255],"category_scores_gemma":[0.002153661,0.0001270786,0.00005040588,0.0009998148,0.0006778441,0.0001032604,0.0007143771,0.002416164,0.000004123197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002380102,"about_ca_system_score_gemma":0.0000655255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002374144,"about_ca_topic_score_gemma":0.000001232469,"domain_scores_codex":[0.9931493,0.003500944,0.0002463264,0.0006874527,0.001732319,0.0006836422],"domain_scores_gemma":[0.9920073,0.006862459,0.0001029149,0.0003926987,0.0002727069,0.0003619131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4104568,0.01315764,0.2907437,0.0002897431,0.0007236212,0.0200623,0.0009816936,0.00008707411,0.09979231,0.001650585,0.008842262,0.1532123],"study_design_scores_gemma":[0.01334247,0.1103027,0.5946013,0.00001844218,0.0001036061,0.001151045,0.0004244954,0.000418708,0.001543768,0.0008210034,0.276875,0.0003974343],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764541,0.0006937847,0.00000530771,0.008054134,0.00003507386,0.001415831,0.00000968805,0.00004562951,0.01328646],"genre_scores_gemma":[0.9895927,0.002981158,0.0001191243,0.003035017,0.00003478291,0.0001993249,0.000008816563,0.00002679788,0.004002328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3971143,"threshold_uncertainty_score":0.9998853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1459774065445147,"score_gpt":0.3963606723373145,"score_spread":0.2503832657927999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}