{"id":"W4205664068","doi":"10.3390/antiox11010102","title":"A Leaky Blood–Brain Barrier to Fibrinogen Contributes to Oxidative Damage in Alzheimer’s Disease","year":2021,"lang":"en","type":"review","venue":"Antioxidants","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Fibrinogen; Blood–brain barrier; Fibrin; Neuroinflammation; Extravasation; Neuroscience; Microglia; Chemistry; Pathology; Biology; Medicine; Inflammation; Immunology; Central nervous system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003682207,0.000856101,0.002889642,0.0009351742,0.0001280287,0.0001177229,0.000398988,0.0002740958,0.0005417286],"category_scores_gemma":[0.001186549,0.0007225109,0.000836038,0.001740718,0.0001024534,0.0001484404,0.0005021575,0.0004991012,0.001503674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002069412,"about_ca_system_score_gemma":0.002293592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001385786,"about_ca_topic_score_gemma":0.00008340375,"domain_scores_codex":[0.995276,0.0005072135,0.000895792,0.001342572,0.0007816822,0.001196691],"domain_scores_gemma":[0.995553,0.0004176947,0.0001677648,0.001189509,0.0002830864,0.002388956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001082644,0.005345185,0.02041884,0.01061845,0.09819143,0.04855117,0.0002854628,0.000002292886,0.00009625087,0.0006050452,0.04379065,0.7710126],"study_design_scores_gemma":[0.003373262,0.0005122009,0.01162167,0.04743726,0.01745183,0.00007093709,0.00007430033,0.000002574036,0.0002820418,0.0000461267,0.9180144,0.001113368],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00542527,0.9867243,0.000008724243,0.0007024221,0.0001163371,0.004685013,0.001742221,0.00007453207,0.000521176],"genre_scores_gemma":[0.003848427,0.9912969,0.0002162483,0.001134518,0.0002045265,0.001013006,0.00154532,0.0001509101,0.0005901537],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8742238,"threshold_uncertainty_score":0.9995226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06660885884627994,"score_gpt":0.392206920131568,"score_spread":0.3255980612852881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}