{"id":"W4205673913","doi":"10.1002/0470846453.ch40","title":"Electron Microscopy and X‐ray Diffraction Studies further Confirm the Efficacy of PTI‐00703 <sup>®</sup> (Cat's Claw Derivative) as a Potential Inhibitor of Alzheimer's β‐Amyloid Protein Fibrillogenesis","year":2001,"lang":"en","type":"other","venue":"","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre","funders":"National Institutes of Health","keywords":"Fibrillogenesis; In vivo; Chemistry; Amyloid β; Amyloid (mycology); Parenchyma; Alzheimer's disease; Fibril; Pathology; Biophysics; Biochemistry; Disease; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007453973,0.000171737,0.0001162523,0.0002127609,0.0001370293,0.0001283143,0.0001593618,0.0001646559,0.002969386],"category_scores_gemma":[0.00008008854,0.00006466419,0.0001571216,0.0001950365,0.0001635802,0.0001192167,0.00007589079,0.0002311507,0.0009567897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000128754,"about_ca_system_score_gemma":0.0001488376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064043,"about_ca_topic_score_gemma":0.001200993,"domain_scores_codex":[0.9999722,0.000002868296,0.000002697909,0.000004756194,0.0000132852,0.000004210513],"domain_scores_gemma":[0.9999299,0.00001685594,0.00001363052,0.00001020747,0.00001743409,0.00001200941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006537028,0.00002031865,0.0001624027,0.00006009834,0.000003293829,0.0001179799,0.00002147664,0.0000551657,0.9951054,0.0001375825,0.00005519917,0.004195743],"study_design_scores_gemma":[0.00002644817,0.0004703723,0.01245694,0.00001304746,0.00001653169,0.00104768,0.00002906903,0.0007179694,0.9766402,0.0001061496,0.00847015,0.000005427354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9380398,0.004380802,0.00848882,0.0001916247,0.00003810997,0.0001916874,0.001566656,0.0002388424,0.04686357],"genre_scores_gemma":[0.9709311,0.002701628,0.009994647,0.00008355863,0.00001063085,0.00005168889,0.001838202,0.0000431659,0.01434526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002969386,"threshold_uncertainty_score":0.009933591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05812384059035292,"score_gpt":0.4045798348170999,"score_spread":0.346455994226747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}