{"id":"W4205690438","doi":"10.1200/jco.2022.40.4_suppl.tps622","title":"Phase 1b expansion study of CX-5461 in patients with solid tumors and <i>BRCA2 </i>and/or <i>PALB2</i> mutation.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; PALB2; Synthetic lethality; DNA repair; PARP inhibitor; Olaparib; Cancer research; Population; Oncology; BRCA mutation; Carcinogenesis; Cancer; Genome instability; Germline mutation; BRCA2 Protein; Prostate cancer; Internal medicine; Mutation; Ovarian cancer; DNA damage; Genetics; Poly ADP ribose polymerase; Biology; Polymerase; Gene; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001547705,0.001716721,0.001701629,0.0005282457,0.000431854,0.0008971723,0.0008102244,0.001674097,0.00823106],"category_scores_gemma":[0.0009517844,0.0006123435,0.001032862,0.0004544627,0.0008350103,0.001063691,0.0005257855,0.003490297,0.001994039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001043182,"about_ca_system_score_gemma":0.001920849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085037,"about_ca_topic_score_gemma":0.001785198,"domain_scores_codex":[0.9995728,0.0001587637,0.00001988711,0.00009650493,0.00003990376,0.0001121063],"domain_scores_gemma":[0.999359,0.00006571918,0.0001093432,0.00005628458,0.00005475183,0.0003548878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5823999,0.1264117,0.009567314,0.001553175,0.001380927,0.0006383379,0.0006801931,0.004843181,0.07431161,0.001043563,0.02149585,0.1756742],"study_design_scores_gemma":[0.4776295,0.4983998,0.009563951,0.00009007157,0.000406172,0.0005169354,0.0001027501,0.001276239,0.003612924,0.0005410477,0.007828969,0.00003164283],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662625,0.004320772,0.002274023,0.001703751,0.0004178672,0.01485206,0.00417323,0.0003896775,0.005606021],"genre_scores_gemma":[0.9632365,0.003070865,0.004004029,0.002876264,0.0002091227,0.01319153,0.006977155,0.0001051888,0.006329357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00823106,"threshold_uncertainty_score":0.02753568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0278695928459738,"score_gpt":0.424719917689044,"score_spread":0.3968503248430703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}