{"id":"W4205701489","doi":"10.1016/j.aca.2021.339370","title":"Investigation of binding of fatty acids to serum albumin to determine free concentrations: Experimental and in-silico approaches","year":2021,"lang":"en","type":"article","venue":"Analytica Chimica Acta","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Human serum albumin; In silico; Linoleic acid; Binding site; Fatty acid-binding protein; Chromatography; Albumin; Fatty acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009880847,0.0008482384,0.0007696329,0.0002931265,0.0003720717,0.0004880774,0.00106029,0.0009297649,0.00144851],"category_scores_gemma":[0.001468016,0.0003986702,0.0009208847,0.0003480784,0.0004026049,0.0004507158,0.0003804236,0.0008171818,0.0005997462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005801763,"about_ca_system_score_gemma":0.0005372301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002717959,"about_ca_topic_score_gemma":0.002808052,"domain_scores_codex":[0.9992409,0.0002020689,0.00004100731,0.0001635494,0.0002696432,0.00008290129],"domain_scores_gemma":[0.9992901,0.0003858312,0.00006798933,0.00006756918,0.0001662992,0.00002218078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001673657,0.0001407848,0.001615876,0.0002813346,0.0000662021,0.0000927208,0.00004974445,0.006448953,0.9861923,0.0005289947,0.0001205472,0.004295185],"study_design_scores_gemma":[0.00001048364,0.0001339415,0.001080863,0.00000734995,0.00004969686,0.0001017095,0.00003358693,0.04461826,0.9529126,0.0001682914,0.0008687676,0.00001446839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8713312,0.001347349,0.1226044,0.0003875978,0.00006467338,0.00008532223,0.0008112731,0.0004683857,0.002899775],"genre_scores_gemma":[0.9596678,0.001065988,0.03687098,0.0001154871,0.00001220706,0.0000745923,0.0005682728,0.00005887263,0.001565862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002717959,"threshold_uncertainty_score":0.005404294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03578324685667934,"score_gpt":0.2690519424310825,"score_spread":0.2332686955744032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}