{"id":"W4205704998","doi":"10.1002/chem.202104111","title":"Continuous Flow Bioconjugations of NIR‐AZA Fluorophores via Strained Alkyne Cycloadditions with Intra‐Chip Fluorogenic Monitoring**","year":2022,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Stephen's University","funders":"Science Foundation Ireland","keywords":"Tetrazine; Bioconjugation; Chemistry; Azide; Bioorthogonal chemistry; Fluorophore; Reagent; Alkyne; Combinatorial chemistry; Fluorescence; Microreactor; Click chemistry; Peptide; Catalysis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003482866,0.0003848919,0.0003776535,0.00004600197,0.001092167,0.0001049201,0.0008911318,0.0000597408,0.01036274],"category_scores_gemma":[0.00009145923,0.0003949454,0.0002740193,0.0003847663,0.0003028407,0.0001035544,0.0002349802,0.001254102,0.00002357321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001789013,"about_ca_system_score_gemma":0.0002099441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004145959,"about_ca_topic_score_gemma":3.070581e-7,"domain_scores_codex":[0.997565,0.00008492101,0.0008317157,0.0004818648,0.0005465932,0.0004898784],"domain_scores_gemma":[0.9978516,0.0001147213,0.0006555055,0.0007428117,0.0002382445,0.000397095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000902859,0.0004122997,0.0004519622,0.0001169899,0.0002163161,0.0001983689,0.0002946971,0.0005410923,0.9900522,0.000008763336,0.002117882,0.005499111],"study_design_scores_gemma":[0.001776506,0.00007376211,0.0002413792,0.0001511344,0.0001884753,0.003008457,0.001859147,0.0004056946,0.9773555,0.0001449032,0.01426937,0.0005256074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824495,0.0004134775,0.0006211073,0.0003174623,0.00007766513,0.00009960314,0.0009062978,0.0001494129,0.01496551],"genre_scores_gemma":[0.9942526,0.00006903996,0.002061035,0.00002466072,0.001010279,0.00007945693,0.0004424722,0.00009825338,0.001962199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01300331,"threshold_uncertainty_score":0.9998502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009639241753549306,"score_gpt":0.2072561426406829,"score_spread":0.1976169008871336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}