{"id":"W4205704998","doi":"10.1002/chem.202104111","title":"Continuous Flow Bioconjugations of NIR‐AZA Fluorophores via Strained Alkyne Cycloadditions with Intra‐Chip Fluorogenic Monitoring**","year":2022,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Stephen's University","funders":"Science Foundation Ireland","keywords":"Tetrazine; Bioconjugation; Chemistry; Azide; Bioorthogonal chemistry; Fluorophore; Reagent; Alkyne; Combinatorial chemistry; Fluorescence; Microreactor; Click chemistry; Peptide; Catalysis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005472111,0.0007690972,0.0003692963,0.0002206253,0.0001269092,0.0004484864,0.0004207679,0.0004225919,0.0008102754],"category_scores_gemma":[0.0003101486,0.000316817,0.0003018838,0.0002398021,0.0004293769,0.0004038413,0.0003401993,0.0007113877,0.0003772746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005934801,"about_ca_system_score_gemma":0.0002158222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005731398,"about_ca_topic_score_gemma":0.0008677064,"domain_scores_codex":[0.999703,0.0000423674,0.0000187515,0.00008982343,0.0000743079,0.00007173995],"domain_scores_gemma":[0.9997714,0.00007381193,0.00007215628,0.00003523659,0.00002784516,0.00001953942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004430701,0.00001783201,0.00003504469,0.00003708032,0.000004332229,0.00003006426,0.00002026309,0.0001913852,0.9972608,0.0002560145,0.00004918536,0.002053687],"study_design_scores_gemma":[0.000004548244,0.00005018286,0.0001492323,0.000001046706,0.000003746668,0.00002478865,0.000001989194,0.0008716118,0.9982055,0.00001700134,0.0006660594,0.000004313384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9025673,0.00167268,0.09066698,0.0001603383,0.00008908378,0.0001958564,0.0003105548,0.0007409612,0.003596392],"genre_scores_gemma":[0.9403019,0.001300733,0.05360455,0.00009372783,0.00003534599,0.000237815,0.0003065791,0.0001123954,0.00400701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008102754,"threshold_uncertainty_score":0.004306018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009639241753549306,"score_gpt":0.2072561426406829,"score_spread":0.1976169008871336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}