{"id":"W4205708517","doi":"10.3389/fbioe.2021.787538","title":"Cartilage Tissue Engineering Approaches Need to Assess Fibrocartilage When Hydrogel Constructs Are Mechanically Loaded","year":2022,"lang":"en","type":"review","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; University of Saskatchewan","keywords":"Fibrocartilage; Hyaline cartilage; Cartilage; Extracellular matrix; Mechanotransduction; Regeneration (biology); Tissue engineering; Hyaline; Cell biology; Chemistry; Biomedical engineering; Aggrecan; Anatomy; Pathology; Osteoarthritis; Articular cartilage; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001991918,0.0007456956,0.002430475,0.001463397,0.00007080665,0.00003658159,0.000311342,0.001193243,0.00002614675],"category_scores_gemma":[0.0001390154,0.0007158666,0.0002178615,0.0007909077,0.00007141666,0.00005293852,0.0003534944,0.001039782,0.000008210677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003337722,"about_ca_system_score_gemma":0.00009547084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004598277,"about_ca_topic_score_gemma":0.000002970389,"domain_scores_codex":[0.9974183,0.00003542883,0.0006593951,0.0009022822,0.000238455,0.0007460663],"domain_scores_gemma":[0.9988863,0.00005364848,0.0001626472,0.0006181201,0.00001288804,0.0002664165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004247002,0.0001063436,0.00001630163,0.007814836,0.000225548,0.001055144,0.00009239975,0.00002666598,0.005181252,0.001116164,0.0004984891,0.9838244],"study_design_scores_gemma":[0.001205159,0.001185636,7.57244e-7,0.005651726,0.0007283277,0.0009816076,0.0003328271,0.0002535771,0.01675776,0.00006744199,0.971903,0.0009322339],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00140411,0.9870995,0.007344526,0.0002716704,0.001213938,0.00186357,0.0001120333,0.0006484337,0.00004220749],"genre_scores_gemma":[0.001471883,0.9298719,0.06717414,0.00005089619,0.0001298213,0.0005960127,0.0002536444,0.0002123776,0.0002393751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9828922,"threshold_uncertainty_score":0.9995292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04547749025753988,"score_gpt":0.2519175907632538,"score_spread":0.2064401005057139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}