{"id":"W4205748672","doi":"10.1002/1873-3468.14279","title":"The T1‐tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel","year":2022,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; European Commission; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Biotechnology and Biological Sciences Research Council; Rosetrees Trust","keywords":"Cytoplasm; Chimera (genetics); Mutant; Sodium channel; Cell biology; Biophysics; Chemistry; Ion channel; Transmembrane domain; Alternative splicing; Biology; Membrane; Sodium; Messenger RNA; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002764566,0.00007691431,0.00008192035,0.00004707519,0.0002074771,0.00001021257,0.0000863213,0.00004209839,0.000015363],"category_scores_gemma":[0.00003539196,0.0000618437,0.00005101227,0.00009101028,0.00009021765,0.000006574349,0.00009283583,0.00006344231,2.919459e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001009085,"about_ca_system_score_gemma":0.00001470109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002178976,"about_ca_topic_score_gemma":0.000004399781,"domain_scores_codex":[0.9992157,0.0001477746,0.0001879824,0.0001653522,0.0001817844,0.0001013575],"domain_scores_gemma":[0.9995831,0.00002015781,0.0001562371,0.0001756355,0.00004258885,0.00002227914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005799757,0.00002610646,0.0004432836,0.00001748131,0.00002417862,1.467044e-7,0.0002475472,0.0006734176,0.9898975,0.00004809071,0.007368718,0.0006735515],"study_design_scores_gemma":[0.001864897,0.001069209,0.02874431,0.0000261952,0.00003671441,0.00000936432,0.003411039,0.001535102,0.8986716,0.0005044209,0.06385107,0.0002760632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942713,0.0003272292,0.003289584,0.001426443,0.0004182294,0.0001651747,0.00001472334,0.000009111175,0.0000782369],"genre_scores_gemma":[0.9990969,0.00004419373,0.0000785473,0.0002499119,0.0001291326,0.00004004658,0.0001526886,0.00001044284,0.0001981578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09122588,"threshold_uncertainty_score":0.2521913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008702754142931823,"score_gpt":0.20985928904573,"score_spread":0.2011565349027982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}