{"id":"W4205775630","doi":"10.1186/s12916-021-02193-0","title":"Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis","year":2022,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"Medical Research Council; St. George's, University of London; Universität Potsdam; Faculty of Medicine and Health, University of Sydney; Johns Hopkins Bloomberg School of Public Health; Agence Nationale de la Recherche; National Institute for Health and Care Research; Singapore Institute for Clinical Sciences; Stanley Center for Psychiatric Research, Broad Institute; Agency for Science, Technology and Research; National Cancer Institute; University of Bristol; Oulun Yliopisto; University of Toronto; World Health Organization; Cancer Research UK; University College London; British Heart Foundation; Massachusetts General Hospital; University Hospitals Bristol NHS Foundation Trust; Turun Yliopisto; University of Oxford; Norges Teknisk-Naturvitenskapelige Universitet; Imperial College London; Helsingin Yliopisto; Broad Institute; Johns Hopkins University","keywords":"Medicine; Mendelian randomization; Oncology; Internal medicine; Bioinformatics; Gene; Genetics; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06636828,0.002439298,0.005949811,0.00297203,0.001168368,0.001644712,0.002963835,0.002403934,0.01004214],"category_scores_gemma":[0.09019282,0.001336584,0.01122895,0.002860627,0.001783209,0.001176732,0.001618802,0.00221273,0.0007102093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001125239,"about_ca_system_score_gemma":0.001710717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004330272,"about_ca_topic_score_gemma":0.001786571,"domain_scores_codex":[0.9103193,0.07134278,0.00276563,0.01044932,0.003523151,0.001599817],"domain_scores_gemma":[0.9289381,0.05367516,0.004935736,0.01021119,0.001543457,0.000696364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1585721,0.001627141,0.4117879,0.003922115,0.2010397,0.005967381,0.001398262,0.05874228,0.008545202,0.03489118,0.009899655,0.1036071],"study_design_scores_gemma":[0.05122536,0.01872739,0.1591475,0.0006562676,0.1271824,0.006311562,0.0004754057,0.5812172,0.003258701,0.03993501,0.01125711,0.0006060466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6857837,0.005834559,0.29523,0.001029221,0.0004213973,0.004860908,0.00314546,0.001467427,0.002227299],"genre_scores_gemma":[0.9067546,0.0006476713,0.08553813,0.0002824121,0.00009556179,0.004035375,0.001161369,0.0001307648,0.00135418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06636828,"threshold_uncertainty_score":0.3509932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110812075238967,"score_gpt":0.2408416098988946,"score_spread":0.2297334891465049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}