{"id":"W4205797796","doi":"10.1002/alz.058710","title":"Insertion of the Icelandic mutation (A673T) in the <i>APP</i> gene using the CRISPR/Cas9 base editing and Prime editing technologies, a preventive treatment for Alzheimer?","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"CRISPR; Mutation; Genome editing; Genetics; Gene; Amyloid precursor protein; Biology; Exon; Cas9; Gene mutation; Molecular biology; Alzheimer's disease; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002995861,0.0005434013,0.0004306258,0.0002411672,0.0002494724,0.000492809,0.0002380843,0.0005483838,0.001926856],"category_scores_gemma":[0.000200316,0.0001928179,0.0005651989,0.0001579115,0.0003123941,0.0001957107,0.000316958,0.0008755612,0.0007672313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348369,"about_ca_system_score_gemma":0.0003315908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695602,"about_ca_topic_score_gemma":0.001511963,"domain_scores_codex":[0.999745,0.00003084814,0.00002977296,0.00007274289,0.00008749199,0.0000341592],"domain_scores_gemma":[0.9998372,0.00002556095,0.00007171866,0.00002323462,0.00002458715,0.00001769421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001148948,0.00002886298,0.0002974725,0.0001027681,0.00002149415,0.0001853233,0.0000236364,0.0002605481,0.9929315,0.0002356338,0.000294191,0.005503585],"study_design_scores_gemma":[0.00001903187,0.000310637,0.00239878,0.00002702684,0.00007548896,0.0006970746,0.00002706708,0.001097573,0.9856563,0.0000911661,0.00958241,0.00001756833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9273226,0.004303235,0.05295769,0.0005202881,0.000764916,0.0002759314,0.002073555,0.0008316925,0.01095016],"genre_scores_gemma":[0.9420449,0.003378648,0.04011738,0.0004737714,0.00007371206,0.0001149633,0.002658339,0.0002443725,0.0108941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926856,"threshold_uncertainty_score":0.006446004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217429260278361,"score_gpt":0.3010779164214963,"score_spread":0.2793349903936602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}