{"id":"W4205821233","doi":"10.1093/jnci/djac011","title":"Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis","year":2022,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"National Cancer Institute; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; National Health and Medical Research Council; Chonnam National University Hwasun Hospital; Centers for Disease Control and Prevention; Biobanco Vasco; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Ministerstvo Zdravotnictví Ceské Republiky; University Hospitals Bristol NHS Foundation Trust; Canadian Institutes of Health Research; Cancerfonden; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Medizinische Universität Graz; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; Karl-Franzens-Universität Graz; University of Bristol; Imperial College London; Food Standards Agency; Division of Cancer Prevention, National Cancer Institute; Harvard T.H. Chan School of Public Health; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Ligue Contre le Cancer; McGill University; Univerzita Karlova v Praze; Deutsches Krebsforschungszentrum; Mike and Josie Harper Cancer Research Institute; National Institutes of Health; Florida Department of Health; University of Cambridge; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Pelotonia; Moffitt Cancer Center; Brigham and Women's Hospital; Wageningen University and Research; Cancer Research UK; American Cancer Society; Chonnam National University; University of South Florida; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Medicine; Hyperinsulinemia; Internal medicine; Type 2 diabetes; Glycemic; Glycated hemoglobin; Observational study; Diabetes mellitus; Colorectal cancer; Causality (physics); Oncology; Insulin; Endocrinology; Cancer; Insulin resistance; Biology; Genetics; Gene; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04301246,0.001734096,0.003050292,0.002172768,0.0007698187,0.001056164,0.001529239,0.001239585,0.005558187],"category_scores_gemma":[0.07329983,0.001008165,0.005568578,0.00184345,0.001066018,0.0007929659,0.0008882623,0.00128052,0.0004007652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008108871,"about_ca_system_score_gemma":0.001179314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0047146,"about_ca_topic_score_gemma":0.002381028,"domain_scores_codex":[0.9308625,0.06017724,0.001445293,0.004601669,0.002211589,0.0007018109],"domain_scores_gemma":[0.9313754,0.05575832,0.004636879,0.006663711,0.0011003,0.0004653034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06906815,0.001418235,0.5832301,0.001648813,0.09888095,0.008155747,0.00153581,0.04452556,0.01059564,0.0293178,0.009117017,0.1425061],"study_design_scores_gemma":[0.02100732,0.009631341,0.2339108,0.0003666914,0.04431875,0.01002005,0.0003481556,0.6336957,0.002476841,0.03725173,0.006483207,0.000489243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7188932,0.002830424,0.2709638,0.001107759,0.0002636253,0.001673095,0.001284519,0.001162086,0.001821405],"genre_scores_gemma":[0.9199657,0.0004912129,0.07674883,0.0003001881,0.0001165674,0.0008747051,0.0006209125,0.0001106934,0.0007711229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04301246,"threshold_uncertainty_score":0.2274743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02690704425189283,"score_gpt":0.3174720701469353,"score_spread":0.2905650258950425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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