{"id":"W4205821347","doi":"10.1200/jco.2021.39.15_suppl.e16122","title":"Landmark analysis of overall survival (OS) by objective response (OR) in previously treated patients (pts) with advanced hepatocellular carcinoma (aHCC): Post hoc analysis of the randomized, phase 3 KEYNOTE-240 study.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Post-hoc analysis; Landmark; Post hoc; Placebo; Internal medicine; Clinical trial; Oncology; Cartography; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006360366,0.0015339,0.002340443,0.0003580761,0.0002783819,0.0008619024,0.001128743,0.0008511024,0.004588259],"category_scores_gemma":[0.00330555,0.0004952474,0.003767577,0.0004705852,0.0008286234,0.001081589,0.0009205144,0.002696921,0.0004883045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001008757,"about_ca_system_score_gemma":0.00149491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005913859,"about_ca_topic_score_gemma":0.001485255,"domain_scores_codex":[0.9979854,0.001338963,0.00007558546,0.0002880477,0.0001229418,0.0001891554],"domain_scores_gemma":[0.9968161,0.0008590603,0.001012145,0.0005577525,0.0001538851,0.0006009798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9796779,0.002155663,0.006137447,0.0002366845,0.002929154,0.00002999823,0.00003361699,0.0009000871,0.002204465,0.00009594086,0.0008590903,0.004739995],"study_design_scores_gemma":[0.5259073,0.3785342,0.07633299,0.00005746281,0.007262746,0.000146813,0.00009756861,0.004640978,0.003648313,0.0006117485,0.002666989,0.00009297791],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923248,0.001198888,0.001221017,0.0001817823,0.0001395206,0.001504815,0.00244193,0.00009717328,0.0008900376],"genre_scores_gemma":[0.9925665,0.0002800969,0.001512044,0.0001927124,0.0001372614,0.002011813,0.002278874,0.00003269106,0.0009880557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006360366,"threshold_uncertainty_score":0.03363723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06621968003366781,"score_gpt":0.3826547853940737,"score_spread":0.3164351053604059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}