{"id":"W4205827567","doi":"10.3390/cells11020299","title":"Sacsin Deletion Induces Aggregation of Glial Intermediate Filaments","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología; Consejo Nacional de Ciencia y Tecnología","keywords":"Intermediate filament; Vimentin; Neurofilament; Ataxia; Glial fibrillary acidic protein; Neuroscience; Biology; Cell biology; Pathology; Chemistry; Medicine; Cytoskeleton; Genetics; Cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000559414,0.00004103527,0.00004155713,0.00002456516,0.00003853094,0.000004728001,0.00006555179,0.00002357378,0.0002042878],"category_scores_gemma":[0.00001103937,0.00004398834,0.00003615807,0.00004035591,0.00002193522,0.000001726512,0.0000614124,0.00002461889,0.000005805866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009701844,"about_ca_system_score_gemma":0.00002898796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004319926,"about_ca_topic_score_gemma":9.946402e-7,"domain_scores_codex":[0.9996129,0.00003996628,0.00009688035,0.0001005317,0.00009204412,0.00005769928],"domain_scores_gemma":[0.9997774,0.000002330025,0.00006897548,0.00009851243,0.00002314552,0.00002961456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000686256,0.00005188645,0.0007658579,0.00000610436,0.000007593346,6.534908e-7,0.00003448093,0.0003239479,0.991132,0.00001753595,0.003055156,0.004536225],"study_design_scores_gemma":[0.0004992396,0.00014243,0.007413036,0.000003230273,0.000008675094,9.791966e-7,0.00009588765,0.0001613418,0.9745218,0.00007340577,0.01700374,0.00007621333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988418,0.00009752214,0.0001696815,0.00003165744,0.000227265,0.00006896115,0.00002861418,0.000003731926,0.0005307958],"genre_scores_gemma":[0.998686,0.00001733919,0.00004999136,0.0001219643,0.00006211991,0.00001039842,0.0002026473,0.00000503975,0.0008445249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01661011,"threshold_uncertainty_score":0.2236809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007807392687960706,"score_gpt":0.2314471684187105,"score_spread":0.2236397757307498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}