{"id":"W4205827567","doi":"10.3390/cells11020299","title":"Sacsin Deletion Induces Aggregation of Glial Intermediate Filaments","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología; Consejo Nacional de Ciencia y Tecnología","keywords":"Intermediate filament; Vimentin; Neurofilament; Ataxia; Glial fibrillary acidic protein; Neuroscience; Biology; Cell biology; Pathology; Chemistry; Medicine; Cytoskeleton; Genetics; Cell","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168527,0.0004727978,0.0001889756,0.0003114051,0.0001379925,0.0001679627,0.0001732143,0.0003446708,0.00134842],"category_scores_gemma":[0.0001202761,0.0001841349,0.0002186716,0.0001400285,0.0002073443,0.00009284186,0.0002243053,0.0003042566,0.0003702177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188669,"about_ca_system_score_gemma":0.0001510007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008726402,"about_ca_topic_score_gemma":0.001476673,"domain_scores_codex":[0.9998165,0.0000324962,0.0000265669,0.00004218005,0.00004863152,0.00003369326],"domain_scores_gemma":[0.9997796,0.00004667568,0.00007714638,0.00002659814,0.00001670474,0.00005324712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007019139,0.00001221819,0.00009525602,0.0000154613,0.000004310167,0.0001601033,0.000009770685,0.00002840565,0.9993025,0.00005040463,0.00002113175,0.0002303261],"study_design_scores_gemma":[0.00002889036,0.0004730991,0.007667496,0.00001036185,0.00002118301,0.001280281,0.00004059685,0.001024882,0.9866066,0.00007152813,0.002767649,0.00000737743],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971027,0.0004517942,0.001306827,0.0000365558,0.00002562315,0.00001388517,0.0002523077,0.00008126945,0.00072897],"genre_scores_gemma":[0.996012,0.0003844445,0.000997109,0.00002588651,0.000008168802,0.00001820246,0.000460165,0.00002877062,0.002065276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00134842,"threshold_uncertainty_score":0.00451088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007807392687960706,"score_gpt":0.2314471684187105,"score_spread":0.2236397757307498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}