{"id":"W4205835660","doi":"10.3390/ijms23020920","title":"Reduced Colonic Mucosal Injury in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase (TIPARP/PARP7)-Deficient Mice","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Aryl hydrocarbon receptor; Inflammation; Immune system; Poly ADP ribose polymerase; Biology; Receptor; Chemokine; Signal transduction; CXCL1; Chemistry; Immunology; Molecular biology; Biochemistry; Polymerase; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000332052,0.001491254,0.0007822057,0.001620836,0.0003805751,0.0007041278,0.0005308178,0.001612414,0.004493908],"category_scores_gemma":[0.0002810283,0.0008441576,0.0009783072,0.0004302647,0.0006201274,0.0007160113,0.000440706,0.002282531,0.00121538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005032264,"about_ca_system_score_gemma":0.0003350817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006301524,"about_ca_topic_score_gemma":0.0008891539,"domain_scores_codex":[0.9993649,0.00005971669,0.00007881762,0.0002374574,0.0001321133,0.0001269177],"domain_scores_gemma":[0.9991731,0.00005021809,0.0002959641,0.0000622514,0.00006194984,0.0003564994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000567035,0.0002241464,0.0002981441,0.00007628729,0.00001958979,0.0001472919,0.0000300039,0.0001099158,0.9970856,0.00009753358,0.00009385859,0.001250487],"study_design_scores_gemma":[0.0005173386,0.006922296,0.02845894,0.0001315272,0.0002400475,0.002546583,0.0002475093,0.00404589,0.9502895,0.0004099114,0.006124865,0.00006554998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985885,0.002026966,0.006307139,0.0004495223,0.0001763529,0.000119034,0.002819417,0.0007682712,0.001448125],"genre_scores_gemma":[0.9726414,0.002517973,0.008112864,0.0004233279,0.00007003775,0.0002958163,0.003875889,0.0003497729,0.01171289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004493908,"threshold_uncertainty_score":0.01503366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906600477677311,"score_gpt":0.3353203956839046,"score_spread":0.3162543909071315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}