{"id":"W4205850289","doi":"10.1101/2022.01.12.22269196","title":"Patients with Alzheimer’s disease have increased cellular amyloid uptake","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Alzheimer's Disease Neuroimaging Initiative; Amyloid (mycology); Disease; Cerebrospinal fluid; Alzheimer's disease; Intracellular; β amyloid; Internal medicine; Medicine; Endocrinology; Neuroscience; Psychology; Pathology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002596729,0.0003395935,0.0002877339,0.0004414869,0.0001949326,0.0005687547,0.00009345563,0.0003220743,0.004116428],"category_scores_gemma":[0.0008274789,0.00009105263,0.000222716,0.0004203003,0.0001681925,0.0001919885,0.0001684104,0.0002495283,0.001046958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412104,"about_ca_system_score_gemma":0.00009276637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007977411,"about_ca_topic_score_gemma":0.0004791141,"domain_scores_codex":[0.9998679,0.00002676569,0.00001366216,0.00004268316,0.00002694754,0.00002192544],"domain_scores_gemma":[0.9996606,0.00009074329,0.0001114143,0.00003827515,0.00005476214,0.00004408452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002262736,0.0003291368,0.8655221,0.000219623,0.0002560149,0.001632702,0.0005525198,0.0003889031,0.08310401,0.0004613333,0.003379709,0.04189121],"study_design_scores_gemma":[0.00003664897,0.0003147587,0.9783636,0.00001322994,0.00006500354,0.003341172,0.0003090968,0.0005518938,0.01335526,0.0007853949,0.002853425,0.00001048461],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948663,0.0008915112,0.0007483459,0.0001553879,0.0000310852,0.000006517162,0.0008682036,0.00005403224,0.002378545],"genre_scores_gemma":[0.9974303,0.0002018726,0.0004741241,0.00006365964,0.00002741115,0.000007134728,0.0006783562,0.00000848063,0.00110851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004116428,"threshold_uncertainty_score":0.01377076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03154902326094938,"score_gpt":0.2892794892749857,"score_spread":0.2577304660140363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}