{"id":"W4205864952","doi":"10.1101/2022.01.03.474779","title":"Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Structural Genomics Consortium; Montreal Neurological Institute and Hospital","funders":"","keywords":"Coronavirus; Virology; Biology; Viral replication; Gene knockdown; Viral entry; Kinase; Potency; Coronavirus disease 2019 (COVID-19); Cell culture; Virus; Cell biology; In vitro; Genetics; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247398,0.0005168102,0.0003018547,0.0001683465,0.0001893231,0.0004277301,0.0001492641,0.0002255731,0.004483534],"category_scores_gemma":[0.00009452217,0.000140175,0.0002364771,0.0001540978,0.0001930614,0.0002438614,0.0001618628,0.0005554103,0.001284582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004190988,"about_ca_system_score_gemma":0.0003965695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005202556,"about_ca_topic_score_gemma":0.0008195654,"domain_scores_codex":[0.9999142,0.000007959646,0.000005362748,0.00001957623,0.00003421623,0.00001870928],"domain_scores_gemma":[0.9999709,0.000003836885,0.00000690696,0.000003265207,0.000006260543,0.00000875761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000358996,0.00003281018,0.0002865282,0.00009454611,0.00001155534,0.00004991118,0.00001064297,0.0003905731,0.9942833,0.0003991288,0.0005462326,0.003535773],"study_design_scores_gemma":[0.00003856261,0.0001255019,0.001914278,0.000005999289,0.00001087139,0.0002551045,0.00001222933,0.001714273,0.9862997,0.0001360243,0.009483214,0.000004301251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465091,0.01247288,0.0137621,0.001093791,0.000383752,0.00009759612,0.002959869,0.0003652015,0.02235578],"genre_scores_gemma":[0.9694507,0.003684301,0.005268685,0.0001208394,0.00004784495,0.00006560405,0.002546307,0.00007257276,0.01874317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004483534,"threshold_uncertainty_score":0.01499885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06540703933861994,"score_gpt":0.3313461908496052,"score_spread":0.2659391515109852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}