{"id":"W4205885789","doi":"10.1513/annalsats.202108-980oc","title":"Impact of Concomitant Medication Burden on Tolerability of Disease-targeted Therapy and Survival in Interstitial Lung Disease","year":2022,"lang":"en","type":"article","venue":"Annals of the American Thoracic Society","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Saskatchewan; Centre Hospitalier de l’Université de Montréal; McGill University; University of Calgary; McMaster University; St. Paul's Hospital; University of British Columbia","funders":"Royal Australasian College of Physicians; Austin Medical Research Foundation; Boehringer Ingelheim","keywords":"Medicine; Tolerability; Concomitant; Polypharmacy; Discontinuation; Internal medicine; Interstitial lung disease; Idiopathic pulmonary fibrosis; Adverse effect; Regimen; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001048063,0.0001282382,0.0003449403,0.000559045,0.0002734955,0.0004764993,0.0002161406,0.00019523,0.001261848],"category_scores_gemma":[0.003449705,0.00009470271,0.0005998645,0.0008089468,0.0002359996,0.0003045872,0.0003580448,0.0003812307,0.00007438997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005364533,"about_ca_system_score_gemma":0.000533513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01114587,"about_ca_topic_score_gemma":0.01358696,"domain_scores_codex":[0.9990847,0.0002839144,0.000132986,0.00012635,0.0002681055,0.0001038641],"domain_scores_gemma":[0.993869,0.001296858,0.003613915,0.0002207778,0.0003873138,0.000612088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001153801,0.00001071474,0.9983788,0.000009660982,0.00005880734,0.00002180995,0.00001115561,0.00005591958,0.00007182189,0.000005645561,0.0000216755,0.001238643],"study_design_scores_gemma":[0.000002653835,0.00005537789,0.9995152,0.000003779728,0.00002044676,0.0000836048,0.00001144849,0.0002308235,0.00002613963,0.000008134794,0.00004125477,0.000001241381],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984391,0.0006585739,0.00009383634,0.00006170123,0.00000269235,0.000006529835,0.0003608285,0.00000248743,0.0003742226],"genre_scores_gemma":[0.9996532,0.00008208559,0.00004955924,0.00001156229,0.000006316326,0.000002123035,0.000160377,4.751493e-7,0.00003416773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01114587,"threshold_uncertainty_score":0.02216196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05085838747104549,"score_gpt":0.3842071517190743,"score_spread":0.3333487642480288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}