{"id":"W4205902194","doi":"10.2147/jaa.s328653","title":"Real World Biologic Use and Switch Patterns in Severe Asthma: Data from the International Severe Asthma Registry and the US CHRONICLE Study","year":2022,"lang":"en","type":"article","venue":"Journal of Asthma and Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"National Institute of Allergy and Infectious Diseases; Efficacy and Mechanism Evaluation Programme; Sanofi Genzyme; Genentech; Mylan; Eli Lilly and Company; AstraZeneca; Respiratory Effectiveness Group; CSL Behring; Regeneron Pharmaceuticals; Insmed; Teva Pharmaceutical Industries; Gilead Sciences; Sanofi; Amgen; National Heart, Lung, and Blood Institute; AKL Research and Development; Pfizer; GlaxoSmithKline","keywords":"Asthma; Real world data; MEDLINE; Prospective cohort study; Observational study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002763767,0.0002283192,0.0003989413,0.001744825,0.0002843311,0.0007918144,0.0005043244,0.0003581941,0.0009807616],"category_scores_gemma":[0.003982845,0.0002169892,0.0005102419,0.003927525,0.0002894568,0.0007819288,0.0007373913,0.0004549955,0.0002147511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000504184,"about_ca_system_score_gemma":0.0006137696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01087373,"about_ca_topic_score_gemma":0.01370999,"domain_scores_codex":[0.9980873,0.0005737436,0.0004311434,0.000327728,0.0003951916,0.0001847966],"domain_scores_gemma":[0.9911897,0.000760303,0.006471951,0.000634096,0.0005060828,0.0004379349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000519214,0.000008494314,0.9990369,0.00001766106,0.00004423076,0.000009440328,0.000039823,0.00004170387,0.00002077739,0.00001584476,0.0001963804,0.0005169073],"study_design_scores_gemma":[0.000008118337,0.00002616905,0.9993211,0.0000161299,0.00002172677,0.00006154278,0.00009652066,0.00007900832,0.0000231561,0.00001400618,0.0003293565,0.000003167623],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836626,0.0007276055,0.0002152671,0.0001224329,0.000008991878,0.00004673815,0.01424264,0.00001140493,0.0009622424],"genre_scores_gemma":[0.9877556,0.0003066027,0.0002176826,0.00006685693,0.00001505739,0.00006230058,0.01147467,0.00000387632,0.00009732952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01087373,"threshold_uncertainty_score":0.02162087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03047019072575304,"score_gpt":0.2814930585587158,"score_spread":0.2510228678329627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}