{"id":"W4205946547","doi":"10.1186/s13068-022-02107-z","title":"Activity-based protein profiling reveals dynamic substrate-specific cellulase secretion by saprotrophic basidiomycetes","year":2022,"lang":"en","type":"article","venue":"Biotechnology for Biofuels and Bioproducts","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; U.S. Department of Agriculture; Agence Nationale de la Recherche; Royal Society; Directorate for Biological Sciences","keywords":"Cellulase; Lignocellulosic biomass; Glucanase; Biochemistry; Glycoside hydrolase; Enzyme; Secretory protein; Chemistry; Secretion; Hydrolysis; Beta-glucosidase; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360261,0.0003222767,0.000259966,0.0003867159,0.0001088635,0.0004560898,0.0001268695,0.0002884266,0.0003415473],"category_scores_gemma":[0.0001812262,0.0001146785,0.000200561,0.0004539302,0.0001203119,0.0002062863,0.000151322,0.0003171237,0.0002272782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000116178,"about_ca_system_score_gemma":0.00009351742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003817138,"about_ca_topic_score_gemma":0.0003737286,"domain_scores_codex":[0.9998579,0.00001283171,0.0000130817,0.00004911492,0.00004040407,0.00002664966],"domain_scores_gemma":[0.9998723,0.00003194747,0.0000336733,0.0000103379,0.00002770614,0.0000239832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004304651,0.00001457271,0.001021363,0.00001633444,0.00000320202,0.00001651907,0.00001333613,0.00001814315,0.9979964,0.00000487336,0.000009951606,0.0008422207],"study_design_scores_gemma":[0.00001099054,0.0003005184,0.1354665,0.000009640838,0.00003605899,0.0005294032,0.0001167801,0.001786297,0.8606074,0.00005794884,0.001067513,0.0000109935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941365,0.000323867,0.00361656,0.00003220284,0.000005993322,0.00002659101,0.001399457,0.0000442624,0.0004144977],"genre_scores_gemma":[0.9878969,0.0005758788,0.007514243,0.00006515472,0.00001495113,0.0000728774,0.002953121,0.00002398344,0.0008828798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004560898,"threshold_uncertainty_score":0.001142561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100283884479031,"score_gpt":0.1965825489437787,"score_spread":0.1865541604958756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}