{"id":"W4205954025","doi":"10.1200/jco.21.01460","title":"Blood-Based Biomarker Panel for Personalized Lung Cancer Risk Assessment","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Diagnosis and Treatment","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Brock University","funders":"National Cancer Institute","keywords":"Medicine; Internal medicine; Receiver operating characteristic; Lung cancer; Cancer screening; Biomarker; Carcinoembryonic antigen; Oncology; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009978104,0.001123172,0.001875523,0.001413755,0.0002877753,0.001707798,0.0007158721,0.0008275771,0.001019383],"category_scores_gemma":[0.01690069,0.0003374804,0.000743344,0.001055761,0.0002691507,0.0009499997,0.0007941335,0.001037302,0.0004733485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000618195,"about_ca_system_score_gemma":0.0009204535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001447182,"about_ca_topic_score_gemma":0.001502143,"domain_scores_codex":[0.9929751,0.004299574,0.0002728173,0.001159355,0.00112936,0.000163789],"domain_scores_gemma":[0.9926932,0.003782431,0.001357634,0.0009036267,0.0009029617,0.0003602258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006071063,0.0008241172,0.7166979,0.0005633787,0.002301005,0.0002090083,0.00009071399,0.02365877,0.02088112,0.001153278,0.005781176,0.2217684],"study_design_scores_gemma":[0.001219444,0.011299,0.5434152,0.0005559882,0.004626409,0.001939631,0.0001561208,0.3611659,0.04248676,0.008692731,0.02418571,0.0002570519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.776358,0.0234034,0.1769341,0.003353544,0.0004537163,0.001074204,0.009214239,0.001838943,0.007369859],"genre_scores_gemma":[0.9455619,0.001251694,0.0488602,0.001015996,0.0002116559,0.0002383512,0.002232693,0.00003415546,0.00059329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009978104,"threshold_uncertainty_score":0.0527699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1663937033088291,"score_gpt":0.5327343387159769,"score_spread":0.3663406354071478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}