{"id":"W4205954990","doi":"10.1016/b978-0-323-99892-5.00014-1","title":"Induced pluripotent stem cells for cystic fibrosis","year":2022,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Induced pluripotent stem cell; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Regenerative medicine; Biology; Stem cell; Cell biology; Drug discovery; Cancer research; Bioinformatics; Computational biology; Embryonic stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002804598,0.0006898383,0.000362951,0.0008857783,0.000245031,0.0008133592,0.0004885067,0.0007704676,0.0546173],"category_scores_gemma":[0.0001740834,0.0002365313,0.0002821317,0.0006615571,0.000233939,0.001023947,0.0005988366,0.001555027,0.02864478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002735672,"about_ca_system_score_gemma":0.0002959422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004344211,"about_ca_topic_score_gemma":0.001136419,"domain_scores_codex":[0.9999011,0.000006607211,0.000007064666,0.00001281138,0.00006629506,0.000006235301],"domain_scores_gemma":[0.9999396,0.00002757378,0.000004582911,0.000006148905,0.00001421971,0.000008050826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006303458,0.00006219336,0.00008091624,0.0007252134,0.000009892046,0.0003311893,0.0001203128,0.0004568576,0.0554929,0.03926111,0.125624,0.7777724],"study_design_scores_gemma":[0.000007943732,0.00002072641,0.0002008352,0.0001684826,0.000007970428,0.0005318091,0.00001570274,0.0001354012,0.006520781,0.005566788,0.9868188,0.000004922198],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.004814915,0.2205232,0.04889342,0.004690018,0.006686422,0.0001756266,0.001858114,0.0009838376,0.7113745],"genre_scores_gemma":[0.006431238,0.0705978,0.01149002,0.001109661,0.0006673436,0.00009340724,0.0008469645,0.0001858958,0.9085777],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0546173,"threshold_uncertainty_score":0.1827131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180416816480664,"score_gpt":0.2532974896312135,"score_spread":0.2314933214664068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}