{"id":"W4205958713","doi":"10.12688/wellcomeopenres.16986.1","title":"Anti-TNF therapy for inflammatory bowel disease in patients with neurodegenerative Niemann-Pick disease Type C","year":2022,"lang":"en","type":"preprint","venue":"Wellcome Open Research","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital; University of Alberta","funders":"King Saud bin Abdulaziz University for Health Science; Ministry of National Guard Health Affairs; Ministry of Education – Kingdom of Saudi Arabi; Deutsche Forschungsgemeinschaft; Wellcome; Royal Society; National Institute for Health and Care Research; Leona M. and Harry B. Helmsley Charitable Trust; Wellcome Trust","keywords":"Peripheral blood mononuclear cell; Medicine; Inflammation; Disease; Gastroenterology; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002465643,0.0001580373,0.000424003,0.0003789239,0.0003025915,0.0003272531,0.0001294891,0.0002820102,0.0008868264],"category_scores_gemma":[0.0005419104,0.00006441382,0.0002633191,0.0004413285,0.0001262307,0.0001453914,0.000107951,0.0002324689,0.0002732086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004515469,"about_ca_system_score_gemma":0.0004359386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001905636,"about_ca_topic_score_gemma":0.003719936,"domain_scores_codex":[0.9998431,0.00003673428,0.00002890327,0.00002500673,0.00003857102,0.00002762879],"domain_scores_gemma":[0.9996189,0.00007482501,0.0001545552,0.00001492862,0.00004986536,0.00008692676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007131218,0.0003728209,0.8967913,0.0004635597,0.000165462,0.005060792,0.0002248212,0.0002143209,0.01432278,0.0001013113,0.002669694,0.07248202],"study_design_scores_gemma":[0.0003118226,0.002987612,0.9746987,0.0001129647,0.0001373061,0.01051969,0.000183048,0.0003113005,0.00319194,0.00006359819,0.007467179,0.0000149142],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906035,0.006339048,0.0001818467,0.0002931689,0.0000241573,0.00006473188,0.0006567701,0.00001660993,0.001819993],"genre_scores_gemma":[0.9952453,0.002205883,0.0005707477,0.0002636927,0.00003548056,0.0000486381,0.001023954,0.000002814019,0.0006035712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905636,"threshold_uncertainty_score":0.003789067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08745077418363988,"score_gpt":0.3883767396565116,"score_spread":0.3009259654728718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}