{"id":"W4205975465","doi":"10.1111/j.1755-3768.2022.205","title":"QR‐421a RNA therapy in retinitis pigmentosa due to mutations in USH2A: Stellar trial Phase[AP1] 1b/2 interim results","year":2022,"lang":"en","type":"article","venue":"Acta Ophthalmologica","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"Retinitis pigmentosa; Medicine; Ophthalmology; Clinical endpoint; Adverse effect; Visual acuity; Randomized controlled trial; Interim analysis; Macular edema; Internal medicine; Retinal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007367576,0.0002244409,0.0003261343,0.0001974201,0.0001386397,0.00002959734,0.0005611381,0.0001532115,0.00004207351],"category_scores_gemma":[0.0003567167,0.0002037925,0.00009836177,0.0005160451,0.00007599038,0.000007797051,0.0005326103,0.0002663789,0.000002298474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007019289,"about_ca_system_score_gemma":0.00006635596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008479234,"about_ca_topic_score_gemma":0.00003640043,"domain_scores_codex":[0.9977148,0.0004112551,0.0005418237,0.0007722301,0.0002090886,0.0003508674],"domain_scores_gemma":[0.9989074,0.00006666029,0.0001734425,0.0007337023,0.00004706804,0.00007167472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02876612,0.002316555,0.0003375714,0.000004972291,0.00007969221,0.00106424,0.0002484197,0.00007445052,0.9451108,0.00001055949,0.002448083,0.01953856],"study_design_scores_gemma":[0.07105869,0.03306105,0.003249466,0.00007395535,0.00005617656,0.00126009,0.002130997,0.0003006923,0.7954796,0.001086309,0.09039749,0.001845494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956766,0.0001389473,0.00004755295,0.001022614,0.0001316806,0.0006356927,0.0002395399,0.00003321949,0.00207412],"genre_scores_gemma":[0.9960504,0.0001468628,0.001925614,0.0003740875,0.0001168523,0.0001181711,0.0009725978,0.00002058383,0.00027483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1496312,"threshold_uncertainty_score":0.8310416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04434515975425494,"score_gpt":0.3512910760765319,"score_spread":0.306945916322277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}