{"id":"W4205975465","doi":"10.1111/j.1755-3768.2022.205","title":"QR‐421a RNA therapy in retinitis pigmentosa due to mutations in USH2A: Stellar trial Phase[AP1] 1b/2 interim results","year":2022,"lang":"en","type":"article","venue":"Acta Ophthalmologica","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"Retinitis pigmentosa; Medicine; Ophthalmology; Clinical endpoint; Adverse effect; Visual acuity; Randomized controlled trial; Interim analysis; Macular edema; Internal medicine; Retinal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002429245,0.0007712418,0.001260565,0.000255923,0.0003786509,0.0009246639,0.0004739736,0.001400022,0.009384054],"category_scores_gemma":[0.001275001,0.0002887688,0.001293462,0.0001681627,0.000442146,0.0006543279,0.0003040582,0.002001967,0.001337651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003284011,"about_ca_system_score_gemma":0.0008943731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000338256,"about_ca_topic_score_gemma":0.0007469994,"domain_scores_codex":[0.9995514,0.0002264013,0.00003194648,0.00005757428,0.00006190706,0.0000707803],"domain_scores_gemma":[0.9993042,0.0001857719,0.0001549327,0.00006355828,0.0001054117,0.0001860799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6743245,0.02469475,0.004014417,0.004146668,0.001954087,0.0003032809,0.0002999256,0.001655746,0.06722151,0.001430345,0.03284023,0.1871145],"study_design_scores_gemma":[0.6196715,0.3444105,0.007937002,0.0003714071,0.0006677851,0.0004558392,0.0000812444,0.001112903,0.007728736,0.001011933,0.01651281,0.00003843603],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447542,0.01432103,0.003281301,0.00349766,0.00101775,0.01054413,0.008662596,0.0006268031,0.01329442],"genre_scores_gemma":[0.9364917,0.007049062,0.009155974,0.006434277,0.001017643,0.01486838,0.01115532,0.0001817635,0.01364581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009384054,"threshold_uncertainty_score":0.03139281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04434515975425494,"score_gpt":0.3512910760765319,"score_spread":0.306945916322277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}