{"id":"W4205984616","doi":"10.1017/cjn.2021.339","title":"P.059 Results From the Randomized and Open-Label Periods of the CENTAUR Trial of Sodium Phenylbutyrate and Ursodoxicoltaurine in Amyotrophic Lateral Sclerosis (ALS)","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Adverse effect; Randomized controlled trial; Amyotrophic lateral sclerosis; Internal medicine; Hazard ratio; Clinical endpoint; Incidence (geometry); Confidence interval; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00334913,0.0006742146,0.001257085,0.0002760855,0.0002979849,0.001003228,0.0004620009,0.001163314,0.02555666],"category_scores_gemma":[0.004088332,0.0003317521,0.001383982,0.0004625491,0.0007689987,0.0006963259,0.0005933877,0.001591729,0.001576152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004237262,"about_ca_system_score_gemma":0.0009647438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004354709,"about_ca_topic_score_gemma":0.0007635197,"domain_scores_codex":[0.9980623,0.001272828,0.0001304007,0.0002203209,0.0001592247,0.0001549469],"domain_scores_gemma":[0.9969299,0.001369666,0.0007606193,0.0002117367,0.0001970907,0.0005310315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9696805,0.001111123,0.001764349,0.0008523362,0.001371541,0.00004422457,0.00003418446,0.000139441,0.001576673,0.0001666711,0.003352653,0.01990635],"study_design_scores_gemma":[0.8407523,0.1139005,0.02800931,0.0002625736,0.003580387,0.0001316929,0.00006991097,0.0005232386,0.001574141,0.0006064539,0.01055771,0.00003179391],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9432098,0.0160304,0.001386922,0.003102924,0.00202707,0.004513043,0.01062547,0.0002528817,0.01885157],"genre_scores_gemma":[0.981521,0.001724227,0.001350266,0.001401989,0.0005334723,0.003255629,0.003388453,0.00005132666,0.006773692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02555666,"threshold_uncertainty_score":0.08549553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08768551851127926,"score_gpt":0.3140761970940016,"score_spread":0.2263906785827224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}