{"id":"W4205984988","doi":"10.1158/2326-6074.tumimm21-p045","title":"Abstract P045: Preclinical transcriptome-based evaluation of the translatable potential of new treatments in Triple-Negative Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Transcriptome; Cancer research; Gene expression profiling; Gene signature; Triple-negative breast cancer; CD44; Breast cancer; Biology; Cancer; Gene expression; Significance analysis of microarrays; Gene; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003511424,0.0004128215,0.0005255581,0.0002822221,0.000213679,0.0003830872,0.0002076717,0.000319929,0.004167994],"category_scores_gemma":[0.0001268047,0.0001475154,0.0003573264,0.0002267853,0.0002272667,0.0002075636,0.0001418757,0.0009311328,0.0006426616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718185,"about_ca_system_score_gemma":0.0004847885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008807108,"about_ca_topic_score_gemma":0.001339235,"domain_scores_codex":[0.9998569,0.0000257027,0.000007765115,0.00002660183,0.00005203941,0.00003089688],"domain_scores_gemma":[0.9999042,0.00001416022,0.00001658541,0.00001249997,0.00002233785,0.00003033989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002333168,0.0007957278,0.0005125928,0.0001953442,0.0000380282,0.00003735224,0.00002523622,0.0005244056,0.9849374,0.0001063321,0.0008069216,0.009687567],"study_design_scores_gemma":[0.0004420715,0.02300605,0.01401657,0.00002821838,0.0002205549,0.0002194095,0.0001109927,0.002877134,0.9495265,0.0001176161,0.009417912,0.0000170998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860138,0.002496699,0.002528307,0.0003058969,0.0001471063,0.0002975485,0.00443527,0.0002101354,0.003565117],"genre_scores_gemma":[0.9827958,0.001766006,0.003907065,0.000257384,0.00003652614,0.0004990904,0.005914018,0.0000791865,0.004744999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004167994,"threshold_uncertainty_score":0.01394337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08245404925804785,"score_gpt":0.4246006050524396,"score_spread":0.3421465557943918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}