{"id":"W4205984988","doi":"10.1158/2326-6074.tumimm21-p045","title":"Abstract P045: Preclinical transcriptome-based evaluation of the translatable potential of new treatments in Triple-Negative Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Transcriptome; Cancer research; Gene expression profiling; Gene signature; Triple-negative breast cancer; CD44; Breast cancer; Biology; Cancer; Gene expression; Significance analysis of microarrays; Gene; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001168818,0.000116307,0.0002327891,0.0001186017,0.000126849,0.000006198482,0.0004481614,0.0001249068,0.0008467063],"category_scores_gemma":[0.000108137,0.0001023007,0.0001415383,0.0003966067,0.0003295193,0.000004854573,0.0001143261,0.0003806005,6.036135e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668632,"about_ca_system_score_gemma":0.003394194,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007776439,"about_ca_topic_score_gemma":0.002038745,"domain_scores_codex":[0.9979448,0.0004836492,0.0003835391,0.0003393014,0.0005213766,0.0003273795],"domain_scores_gemma":[0.9989942,0.00008329265,0.0001325323,0.0004065226,0.0003418441,0.00004164029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004156168,0.000619752,0.02036265,0.00004015364,0.0003995229,0.000001747182,0.0004502895,0.02558458,0.9033486,0.00001907747,0.001616038,0.04340139],"study_design_scores_gemma":[0.01388203,0.0007933277,0.6265405,0.00007459526,0.0001771822,0.000006233941,0.0005604979,0.0009793665,0.3539565,0.0005277619,0.002277905,0.0002240985],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847249,0.01150087,0.00001344216,0.001355157,0.0004573706,0.0007983631,0.0009837546,0.000001928248,0.0001641558],"genre_scores_gemma":[0.9976794,0.001350233,0.00001987671,0.00004642939,0.00007751007,0.000501483,0.00005445075,0.0000182257,0.0002524524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6061778,"threshold_uncertainty_score":0.9988309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08245404925804785,"score_gpt":0.4246006050524396,"score_spread":0.3421465557943918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}