{"id":"W4206011678","doi":"10.1002/chem.202103910","title":"Chloromethyl Glycosides as Versatile Synthons to Prepare Glycosyloxymethyl‐Prodrugs","year":2022,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parks Canada","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Prodrug; Synthon; Chemistry; Monosaccharide; Glycoside; In vivo; Pharmacokinetics; Benzocaine; Pharmacology; Drug; Combinatorial chemistry; Stereochemistry; Organic chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001896454,0.0003780541,0.000141976,0.0001751567,0.00005502113,0.0001658494,0.0001701959,0.0002630925,0.000882632],"category_scores_gemma":[0.0001867899,0.0001420705,0.0002067209,0.000121019,0.0001347081,0.0002513339,0.0001988875,0.000517134,0.0004413476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936501,"about_ca_system_score_gemma":0.0001384843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001999111,"about_ca_topic_score_gemma":0.0003816212,"domain_scores_codex":[0.9998902,0.00002539795,0.000008144952,0.0000178518,0.00003366434,0.00002480776],"domain_scores_gemma":[0.9999003,0.0000174766,0.00003706662,0.00001109568,0.00001740946,0.00001661593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007661668,0.00002146451,0.00008163773,0.00006647248,0.000007153072,0.0001052951,0.00001941085,0.0004015921,0.9946684,0.0005107743,0.0000788242,0.00396241],"study_design_scores_gemma":[0.0000124072,0.0003297122,0.000260655,0.000004824234,0.000008349531,0.0001485262,0.00000806067,0.0003965318,0.9957678,0.00005617724,0.003001287,0.00000569558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527866,0.003678146,0.03613648,0.0002510799,0.0001040959,0.0001993378,0.0004178786,0.0001957786,0.006230622],"genre_scores_gemma":[0.9780747,0.002262191,0.01621309,0.0001170622,0.00002569961,0.00006825944,0.0002853443,0.00005077301,0.002903026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000882632,"threshold_uncertainty_score":0.002952695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009843594237718944,"score_gpt":0.2410534515457632,"score_spread":0.2312098573080442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}