{"id":"W4206034076","doi":"10.1242/jcs.259002","title":"Lipid-driven CFTR clustering is impaired in cystic fibrosis and restored by corrector drugs","year":2022,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Cystic Fibrosis Canada; Natural Sciences and Engineering Research Council of Canada; McGill University; Cystic Fibrosis Foundation","keywords":"Lipid raft; Biology; Cystic fibrosis transmembrane conductance regulator; Cell biology; Cystic fibrosis; Ceramide; Sphingolipid; Cell membrane; Cell; Biochemistry; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001221184,0.00009712637,0.000270556,0.0003802969,0.0002111531,0.00005828646,0.000334162,0.00001800497,0.0001654356],"category_scores_gemma":[0.0004782393,0.00008170406,0.00005301137,0.0008692438,0.0003210641,0.0003200608,0.0002800422,0.0003910848,0.000002470326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004836913,"about_ca_system_score_gemma":0.0004796418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006448809,"about_ca_topic_score_gemma":0.000006580671,"domain_scores_codex":[0.9977083,0.00007651607,0.0003827303,0.0002193881,0.00125298,0.0003600356],"domain_scores_gemma":[0.998913,0.0002404045,0.000229955,0.0001619835,0.0001300445,0.0003246467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000828706,0.0001571188,0.01837921,0.00008344129,0.00000553886,0.00009300502,0.00261141,0.0004631392,0.9643185,0.000001522919,0.008221562,0.004836922],"study_design_scores_gemma":[0.02128734,0.0205201,0.2625829,0.001984814,0.0001916724,0.004086519,0.01776827,0.1736166,0.3771558,0.0005244346,0.1188708,0.00141079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967685,0.001088731,0.0002437312,0.001120868,0.000309661,0.0001726569,0.00001314338,0.000007006937,0.0002757288],"genre_scores_gemma":[0.9942964,0.00009913511,0.004999916,0.0001322673,0.0000673653,0.000007318883,5.563878e-7,0.000009526832,0.0003874558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5871627,"threshold_uncertainty_score":0.3331795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039811669315285,"score_gpt":0.2845550998197316,"score_spread":0.2741569831265788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}