{"id":"W4206035939","doi":"10.1038/s41418-021-00918-5","title":"Epiblast fragmentation by shedding—a novel mechanism to eliminate cells in post-implantation mouse embryos","year":2022,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Israel Science Foundation; University of Toronto","keywords":"Epiblast; Cell biology; Embryo; Embryonic stem cell; Programmed cell death; Biology; Gastrulation; Immunostaining; Apoptosis; Embryogenesis; Chemistry; Immunology; Genetics; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006091546,0.0004220812,0.0004074453,0.0006016039,0.0003148973,0.000466727,0.000536085,0.0007250673,0.0007232223],"category_scores_gemma":[0.0003368715,0.0003020943,0.0005692548,0.0001420182,0.0003543406,0.0005855017,0.0005855313,0.0008777375,0.0001880144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002760505,"about_ca_system_score_gemma":0.0001961389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002017407,"about_ca_topic_score_gemma":0.0002854066,"domain_scores_codex":[0.9996074,0.0000587031,0.0000320215,0.00008905218,0.0001238087,0.00008899088],"domain_scores_gemma":[0.9996792,0.00006630053,0.00009607926,0.00006926079,0.00003264393,0.00005653332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008617396,0.00001612021,0.0002053093,0.00003800903,0.0000109196,0.000101171,0.0000152202,0.00005641561,0.9954308,0.000303744,0.00005310609,0.003683062],"study_design_scores_gemma":[0.00004371962,0.000286339,0.003444917,0.00001103848,0.00002725331,0.001109358,0.00002208963,0.002148703,0.9901258,0.0001943572,0.002576084,0.00001035381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9053006,0.006977237,0.08289623,0.000404898,0.000212213,0.0003101229,0.0004386743,0.0007256386,0.002734398],"genre_scores_gemma":[0.9737028,0.001568787,0.02058007,0.0001840577,0.00005058406,0.0001303127,0.0003166129,0.0000775613,0.00338912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007250673,"threshold_uncertainty_score":0.003221571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008056129572028146,"score_gpt":0.2335365476449286,"score_spread":0.2254804180729005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}