{"id":"W4206037850","doi":"10.1101/2022.01.14.476298","title":"Long dsRNA mediated RNA interference (dsRNAi) is antiviral in interferon competent mammalian cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Wilfrid Laurier University","funders":"","keywords":"Dicer; RNA interference; RNA silencing; Gene knockdown; Biology; Interferon; Small interfering RNA; Cell biology; Transfection; RNA; Ribonuclease III; Virology; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002544076,0.0003365805,0.0003129358,0.0001962665,0.0002153624,0.0004114319,0.0001597175,0.0003702833,0.002989233],"category_scores_gemma":[0.0001421948,0.000163892,0.0003382259,0.0001545675,0.0003059084,0.0002131278,0.0002549452,0.0006600111,0.001912404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593046,"about_ca_system_score_gemma":0.0001507149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001074165,"about_ca_topic_score_gemma":0.0001453015,"domain_scores_codex":[0.9997286,0.00004458612,0.00002660404,0.00006883934,0.0001009651,0.00003042876],"domain_scores_gemma":[0.9999073,0.000022932,0.00002195223,0.00002076766,0.0000132225,0.00001391197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002149179,0.000005502242,0.00004669886,0.00002575459,0.000002481744,0.00002682204,0.000006835385,0.0000195363,0.9989768,0.0002470647,0.00007239651,0.0005486492],"study_design_scores_gemma":[0.00000536073,0.00003730325,0.0005925152,0.000003573026,0.000003360865,0.0001785017,0.000006157136,0.0003775896,0.9927682,0.0001066345,0.005919239,0.0000017405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8363758,0.009425118,0.105565,0.00104344,0.0008506797,0.0002684485,0.004744384,0.001497003,0.04023005],"genre_scores_gemma":[0.9398969,0.002097629,0.02936473,0.0003067871,0.00008716265,0.0002037485,0.00464203,0.0003100093,0.02309099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002989233,"threshold_uncertainty_score":0.00999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282627588231644,"score_gpt":0.2250516567706223,"score_spread":0.2122253808883059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}