{"id":"W4206048897","doi":"","title":"Hepatitis C virus exploits cyclophilin A to evade PKR","year":2020,"lang":"en","type":"article","venue":"UCL Discovery (University College London)","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Health Sciences, Queen's University; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Canadian Institutes of Health Research; European Commission; Wellcome","keywords":"Protein kinase R; Viral replication; Biology; Cypa; Virology; Innate immune system; Hepatitis C virus; NS5A; Interferon; Cyclophilin A; Interferon regulatory factors; Vesicular stomatitis virus; Virus; Host factor; Antiviral protein; Effector; Viral entry; Cell biology; Hepacivirus; Immune system; Protein kinase A; Kinase; Immunology; Genetics; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090783,0.0001818875,0.0001042107,0.0001436367,0.0001530494,0.0003120081,0.00008815702,0.0001875904,0.0009093262],"category_scores_gemma":[0.00006466635,0.00006916403,0.0001207412,0.00008148202,0.0002042984,0.0001360818,0.0002224058,0.0002754689,0.0003470418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002890509,"about_ca_system_score_gemma":0.0001828538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004193132,"about_ca_topic_score_gemma":0.0008259884,"domain_scores_codex":[0.999927,0.00001808503,0.000004249812,0.00001206256,0.00001954699,0.00001896991],"domain_scores_gemma":[0.9999647,0.000005743088,0.000009743018,0.000005213426,0.000003182912,0.00001133319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006510883,0.00001190994,0.0002819672,0.00002040282,0.000004035895,0.00005802265,0.000004712368,0.00009384573,0.9959777,0.0004475163,0.0001255874,0.002909287],"study_design_scores_gemma":[0.00002466295,0.0003634182,0.007698408,0.00001133249,0.00001321111,0.0008195522,0.0000307712,0.003023983,0.9770866,0.0003355637,0.01058388,0.000008579525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796153,0.004168279,0.004942658,0.0007015892,0.00007342031,0.00002540818,0.0001982345,0.0001637105,0.01011146],"genre_scores_gemma":[0.9960951,0.0008744582,0.001101048,0.0000981245,0.00001478341,0.000006623975,0.00009031639,0.000007094421,0.001712572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009093262,"threshold_uncertainty_score":0.003041983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242540946101455,"score_gpt":0.2017390396817487,"score_spread":0.1893136302207342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}