{"id":"W4206048897","doi":"","title":"Hepatitis C virus exploits cyclophilin A to evade PKR","year":2020,"lang":"en","type":"article","venue":"UCL Discovery (University College London)","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Health Sciences, Queen's University; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Canadian Institutes of Health Research; European Commission; Wellcome","keywords":"Protein kinase R; Viral replication; Biology; Cypa; Virology; Innate immune system; Hepatitis C virus; NS5A; Interferon; Cyclophilin A; Interferon regulatory factors; Vesicular stomatitis virus; Virus; Host factor; Antiviral protein; Effector; Viral entry; Cell biology; Hepacivirus; Immune system; Protein kinase A; Kinase; Immunology; Genetics; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006263329,0.0002353506,0.0002222427,0.00006789681,0.0001907639,0.00003257851,0.0005449497,0.0001421696,0.0001199562],"category_scores_gemma":[0.0001538948,0.0002969796,0.0001997508,0.0004453311,0.00007599076,0.0000383993,0.0005111551,0.0001187685,0.0002327508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000646982,"about_ca_system_score_gemma":0.0002002722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001978855,"about_ca_topic_score_gemma":0.0003350996,"domain_scores_codex":[0.9985249,0.00009484124,0.0001389065,0.0006489569,0.0002495993,0.0003428125],"domain_scores_gemma":[0.9989745,0.00002105606,0.00006666118,0.0004237629,0.00007743681,0.0004366052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002644462,0.0003201192,0.01570566,0.00008685451,0.0002681223,0.001013712,0.0007740874,0.001304489,0.8641245,0.002576102,0.1106058,0.0005760744],"study_design_scores_gemma":[0.007082293,0.00241373,0.02617279,0.0001346259,0.0003494881,0.00004568475,0.002490317,0.00119615,0.543739,0.0002609585,0.4134563,0.002658642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898703,0.0001641856,0.004047454,0.001919421,0.0001835433,0.000379597,0.002151145,0.00006204566,0.001222367],"genre_scores_gemma":[0.9917576,0.0001317357,0.0006569882,0.002920615,0.0002644539,0.000004020433,0.0001732699,0.00003631263,0.004054992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3203855,"threshold_uncertainty_score":0.9999482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242540946101455,"score_gpt":0.2017390396817487,"score_spread":0.1893136302207342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}