{"id":"W4206052126","doi":"10.1016/j.jcyt.2021.10.010","title":"Use of CRISPR/Cas9 gene editing to improve chimeric antigen-receptor T cell therapy: A systematic review and meta-analysis of preclinical studies","year":2022,"lang":"en","type":"review","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Canadian Blood Services; Ottawa Hospital","funders":"Canadian Blood Services","keywords":"Chimeric antigen receptor; CRISPR; Genome editing; Genetic enhancement; Cas9; Biology; Immune system; Cancer; Melanoma; Leukemia; Immunotherapy; Cancer research; Immunology; Gene; Computational biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003373564,0.0008925683,0.02164589,0.001091161,0.00009874646,0.00003464951,0.0005404674,0.0002469435,0.008317916],"category_scores_gemma":[0.0008577343,0.0005710903,0.005873967,0.003028417,0.0002341456,0.00007798689,0.0002327225,0.000697319,0.0000128399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001801701,"about_ca_system_score_gemma":0.000344579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005338663,"about_ca_topic_score_gemma":0.000003946909,"domain_scores_codex":[0.9918922,0.001986657,0.003300671,0.001113111,0.00119405,0.0005133293],"domain_scores_gemma":[0.9919624,0.003004755,0.002237736,0.002046091,0.0004733341,0.0002756639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0000829667,0.0003548806,0.000004401777,0.5982124,0.3646176,0.000009756473,0.0004094549,7.856113e-7,0.0009362545,0.000002005881,0.0005348535,0.03483457],"study_design_scores_gemma":[0.0005059533,0.001312639,0.000001464464,0.01527506,0.6134766,0.00001868087,0.00009251394,0.000004404225,0.0005547807,0.00000117857,0.3682904,0.0004663363],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001013342,0.9883972,0.0000301361,0.0001731224,0.0001281233,0.01055706,0.0005448116,0.00003784771,0.0000303352],"genre_scores_gemma":[0.000005461448,0.9920004,0.001012282,0.0009774434,0.000132379,0.002262002,0.0001123344,0.0001951144,0.003302586],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5829374,"threshold_uncertainty_score":0.9996741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4024757174870827,"score_gpt":0.4875841560182612,"score_spread":0.0851084385311785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}