{"id":"W4206062949","doi":"10.1158/2326-6066.cir-21-0332","title":"An <i>In Vivo</i> Screen to Identify Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; National Institutes of Health; McGill University","keywords":"Epitope; Immunogenicity; Peptide; Adjuvant; Peptide vaccine; Antigen; Mimotope; Peptide library; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620741,0.0005061431,0.0003082581,0.0002672012,0.0001134887,0.0002485996,0.000197023,0.0003496345,0.0009009015],"category_scores_gemma":[0.0001585842,0.0001225996,0.0002360883,0.0001602723,0.0001248054,0.0001579109,0.0001930082,0.0003228345,0.0004382294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001319454,"about_ca_system_score_gemma":0.0001358429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001008809,"about_ca_topic_score_gemma":0.0002370555,"domain_scores_codex":[0.9998525,0.00003437455,0.000009119934,0.00003501407,0.0000376531,0.00003126256],"domain_scores_gemma":[0.9998935,0.00002129805,0.00002703514,0.00001557168,0.0000214283,0.00002109864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004501293,0.00005467256,0.000112942,0.00003103832,0.000004216558,0.00002678576,0.000004201626,0.0001198437,0.9977065,0.00004641841,0.00006303783,0.00178535],"study_design_scores_gemma":[0.0000195438,0.001433464,0.000980683,0.000004263191,0.00002140671,0.0001837898,0.00001030489,0.0009262594,0.9940148,0.00003570432,0.002364838,0.000004962765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954284,0.002768836,0.03486956,0.0002817595,0.00007610043,0.0005456563,0.00113818,0.0004344783,0.005601397],"genre_scores_gemma":[0.9529177,0.00230184,0.03729404,0.0003458717,0.00003578645,0.0003051029,0.00150607,0.00006316193,0.005230409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009009015,"threshold_uncertainty_score":0.00301379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04164043390786948,"score_gpt":0.3792380393680357,"score_spread":0.3375976054601663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}