{"id":"W4206063127","doi":"10.1016/j.jaci.2021.11.007","title":"Emerging strategies for treating autoimmune disorders with genetically modified Treg cells","year":2022,"lang":"en","type":"review","venue":"Journal of Allergy and Clinical Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Chimeric antigen receptor; Cell therapy; Immunotherapy; Medicine; Immunology; Treg cell; Genetic enhancement; Genome editing; Clinical trial; T cell; Computational biology; Cell; Biology; Immune system; Bioinformatics; Gene; IL-2 receptor; CRISPR","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001211764,0.0003801336,0.002847675,0.000294899,0.0001773024,0.00004509223,0.0003518262,0.0004917588,0.001485695],"category_scores_gemma":[0.0002156275,0.0002546035,0.001113001,0.000213421,0.0004712352,0.0000687362,0.0001386091,0.001996564,0.00000198839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009625995,"about_ca_system_score_gemma":0.001383739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000184811,"about_ca_topic_score_gemma":0.00003532924,"domain_scores_codex":[0.9963242,0.0005706563,0.001970225,0.0003671432,0.0003154258,0.0004522987],"domain_scores_gemma":[0.9958045,0.002385689,0.001157175,0.0003560086,0.0001512609,0.000145365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002118351,0.0004200906,0.000003075515,0.0008285799,0.00851327,0.00009333813,0.00008300763,0.0000155862,0.00006022814,0.0003096006,0.00007706988,0.9874778],"study_design_scores_gemma":[0.003784868,0.009012721,0.00005812187,0.001629268,0.001402741,0.0005511708,0.0005751499,0.00005641877,0.000001452672,0.0002774905,0.9824087,0.0002418674],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001018377,0.9956135,0.0004398712,0.0003128032,0.0004554616,0.0006023003,0.000006494494,0.00001527219,0.001535905],"genre_scores_gemma":[0.00005511064,0.9962151,0.0009868208,0.00005308189,0.0003033225,0.00004415259,0.00002296369,0.00007992621,0.002239539],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.987236,"threshold_uncertainty_score":0.9999906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07861406624080433,"score_gpt":0.4125092047206484,"score_spread":0.3338951384798441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}