{"id":"W4206063127","doi":"10.1016/j.jaci.2021.11.007","title":"Emerging strategies for treating autoimmune disorders with genetically modified Treg cells","year":2022,"lang":"en","type":"review","venue":"Journal of Allergy and Clinical Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Chimeric antigen receptor; Cell therapy; Immunotherapy; Medicine; Immunology; Treg cell; Genetic enhancement; Genome editing; Clinical trial; T cell; Computational biology; Cell; Biology; Immune system; Bioinformatics; Gene; IL-2 receptor; CRISPR","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007237886,0.0009703171,0.001379723,0.001034614,0.0001913393,0.0008917306,0.001029409,0.001115832,0.002973378],"category_scores_gemma":[0.0005673611,0.0001933372,0.000611969,0.0006655996,0.000470837,0.001006638,0.0005419535,0.003101993,0.001249545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003764198,"about_ca_system_score_gemma":0.000570586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004802464,"about_ca_topic_score_gemma":0.001172964,"domain_scores_codex":[0.9998636,0.00002879574,0.00001341104,0.00002394227,0.0000478402,0.00002229905],"domain_scores_gemma":[0.9998121,0.0001040225,0.00002226104,0.000008019181,0.00003519611,0.00001848863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001927058,0.0001793845,0.0001444472,0.00754032,0.0001272788,0.0001982071,0.0000268907,0.0005339176,0.005499298,0.004973162,0.02501964,0.9555647],"study_design_scores_gemma":[0.0002661319,0.0005569013,0.0007611999,0.002702719,0.0003468655,0.001345572,0.00004253435,0.0003343931,0.002322001,0.004170526,0.9871199,0.00003127413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002499681,0.9974618,0.0006106168,0.0004702325,0.000425487,0.00001075761,0.00002259555,0.00002107509,0.0007275314],"genre_scores_gemma":[0.00237429,0.9941251,0.001062926,0.0008591115,0.0005444296,0.00003196791,0.00007455742,0.000004772409,0.000922744],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002973378,"threshold_uncertainty_score":0.009946942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07861406624080433,"score_gpt":0.4125092047206484,"score_spread":0.3338951384798441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}