{"id":"W4206064730","doi":"10.1159/000521517","title":"Long-Term Efficacy of a Treat-and-Extend Regimen with Ranibizumab in Patients with Neovascular Age-Related Macular Disease: An Open-Label 12-Month Extension to the CANTREAT Study","year":2021,"lang":"en","type":"article","venue":"Ophthalmologica","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada); Montreal Clinical Research Institute; Institut national de psychiatrie légale Philippe-Pinel; University of Alberta; University of Calgary; University of Toronto; Western University; Sunnybrook Health Science Centre","funders":"Novartis Pharmaceuticals Canada","keywords":"Medicine; Ranibizumab; Macular degeneration; Regimen; Diabetic retinopathy; Ophthalmology; Dosing; Internal medicine; Endocrinology; Bevacizumab; Diabetes mellitus; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305957,0.0003366623,0.0006550572,0.00007508411,0.0001391264,0.00006023697,0.0002246115,0.00006204365,0.00013633],"category_scores_gemma":[0.00007335005,0.0001684221,0.00005699351,0.0004152494,0.0001143174,0.000101693,0.0002100908,0.0001340126,0.000005899043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007788066,"about_ca_system_score_gemma":0.0001206144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004446656,"about_ca_topic_score_gemma":0.00005776395,"domain_scores_codex":[0.9977827,0.0002831196,0.000306908,0.0008090751,0.0004880317,0.0003301681],"domain_scores_gemma":[0.9982176,0.00005341339,0.000119102,0.001042838,0.0001704203,0.0003966181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01978036,0.01636068,0.9192047,0.00004209052,0.0005332819,0.03952159,0.0003279636,0.0000341651,0.00004419266,0.000008192151,0.00001146429,0.004131304],"study_design_scores_gemma":[0.02520812,0.01318123,0.9592766,0.0003942029,0.001226407,0.0003004403,0.0001520913,0.00001637325,0.00002165031,0.0000132595,0.000004513809,0.0002050738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947897,0.0009668673,0.000001282458,0.0002336277,0.000014779,0.003288386,0.00003041943,0.00001973027,0.000655183],"genre_scores_gemma":[0.9983066,0.00003741877,0.0001899069,0.00005650174,0.000009582229,0.0001354096,0.0002978706,0.00003904896,0.0009276476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04007192,"threshold_uncertainty_score":0.6868055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03039850431162967,"score_gpt":0.3095061506446238,"score_spread":0.2791076463329941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}