{"id":"W4206079304","doi":"10.3389/fendo.2021.788535","title":"Emerging Insights Into the Role of Epigenetics and Gut Microbiome in the Pathogenesis of Graves’ Ophthalmopathy","year":2022,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Ophthalmology and Eye Disorders","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Program for New Century Excellent Talents in University; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; National Science and Technology Major Project; Guizhou Education Department Youth Science and Technology Talents Growth Project; Petroleum Technology Research Centre; Guizhou Science and Technology Department","keywords":"Epigenetics; DNA methylation; Pathogenesis; Microbiome; Inflammation; Immunology; Biology; Disease; Graves' ophthalmopathy; Histone; Epigenesis; Bioinformatics; Medicine; Graves' disease; Cancer research; Thyroid; Genetics; Gene; Pathology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002878518,0.0003218676,0.00166861,0.0007711109,0.00007605665,0.000002685844,0.0005351444,0.000248554,0.00004361778],"category_scores_gemma":[0.0001113315,0.0002050349,0.0002522818,0.0007174273,0.0006230963,0.00001780798,0.0002474929,0.0007050172,0.000001168278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000062374,"about_ca_system_score_gemma":0.0001650122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001596633,"about_ca_topic_score_gemma":0.00001710536,"domain_scores_codex":[0.9973966,0.0008377086,0.0008227891,0.0004016542,0.0001467515,0.0003944903],"domain_scores_gemma":[0.998703,0.0002690694,0.0003674758,0.0006078362,0.00002378498,0.00002883009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008656587,0.0003257303,0.03437769,0.004624163,0.0003349488,0.0007068594,0.007942135,0.000005896213,0.00007779287,0.0004334145,0.0001084817,0.9509763],"study_design_scores_gemma":[0.0007638401,0.0004585684,0.006873524,0.0008512934,0.0007513944,0.001723604,0.01247817,0.00001237227,0.0000251861,0.003082246,0.9726956,0.0002841787],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04467338,0.953101,0.000004965769,0.00007839268,0.0005352166,0.0007918157,0.00001401698,0.000004983234,0.0007962252],"genre_scores_gemma":[0.02841668,0.9707909,0.0004222118,0.00003915352,0.00002759401,0.0001685317,0.00006736003,0.00003328683,0.00003429624],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9725872,"threshold_uncertainty_score":0.836108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946685007805277,"score_gpt":0.2996914294274242,"score_spread":0.2802245793493714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}