{"id":"W4206079304","doi":"10.3389/fendo.2021.788535","title":"Emerging Insights Into the Role of Epigenetics and Gut Microbiome in the Pathogenesis of Graves’ Ophthalmopathy","year":2022,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Ophthalmology and Eye Disorders","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Program for New Century Excellent Talents in University; National Outstanding Youth Science Fund Project of National Natural Science Foundation of China; National Science and Technology Major Project; Guizhou Education Department Youth Science and Technology Talents Growth Project; Petroleum Technology Research Centre; Guizhou Science and Technology Department","keywords":"Epigenetics; DNA methylation; Pathogenesis; Microbiome; Inflammation; Immunology; Biology; Disease; Graves' ophthalmopathy; Histone; Epigenesis; Bioinformatics; Medicine; Graves' disease; Cancer research; Thyroid; Genetics; Gene; Pathology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004483241,0.0005813013,0.0008335122,0.001375746,0.0002024071,0.0007046682,0.000456836,0.0009302846,0.002439919],"category_scores_gemma":[0.0006150637,0.0001436069,0.0003690861,0.001142752,0.0003361334,0.0009900928,0.0006384678,0.001237991,0.0007538663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004116926,"about_ca_system_score_gemma":0.0008624197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007715722,"about_ca_topic_score_gemma":0.00152882,"domain_scores_codex":[0.9998862,0.0000244617,0.00001675129,0.00001930475,0.0000392818,0.00001397451],"domain_scores_gemma":[0.9997795,0.0001134599,0.00002682931,0.000005405936,0.00005007062,0.00002470206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008725106,0.0000547998,0.0004236436,0.01437461,0.0001224801,0.0004045847,0.0001012155,0.0002772326,0.002236484,0.004570341,0.03031076,0.9470365],"study_design_scores_gemma":[0.00002233848,0.0001072815,0.00238362,0.00411652,0.0001886838,0.002717059,0.000125438,0.0001576195,0.0005162343,0.003587637,0.9860514,0.00002612123],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001380914,0.9985441,0.0001062788,0.0004387325,0.0002079289,0.000002056751,0.00001182202,0.000005892064,0.0005451716],"genre_scores_gemma":[0.0009107154,0.9980624,0.0001314974,0.0002281152,0.0002630687,0.000003758606,0.00002003299,9.418036e-7,0.0003793713],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002439919,"threshold_uncertainty_score":0.00816232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946685007805277,"score_gpt":0.2996914294274242,"score_spread":0.2802245793493714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}