{"id":"W4206125469","doi":"10.2196/32234","title":"Microbial Ecosystem Therapeutic-2 Intervention in People With Major Depressive Disorder and Generalized Anxiety Disorder: Phase 1, Open-Label Study","year":2022,"lang":"en","type":"article","venue":"Interactive Journal of Medical Research","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Providence Health Care","funders":"Mitacs","keywords":"Tolerability; Generalized anxiety disorder; Anxiety; Major depressive disorder; Adverse effect; Microbiome; Medicine; Internal medicine; Rating scale; Depression (economics); Psychiatry; Psychology; Bioinformatics; Mood; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003582121,0.0001321224,0.0003209218,0.0002142599,0.0002469018,0.00009325508,0.0007121403,0.00008011625,0.0003428948],"category_scores_gemma":[0.0002642052,0.00009929902,0.00005018454,0.0002467943,0.00007665319,0.00002512191,0.0009714961,0.001124364,0.000001242623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229667,"about_ca_system_score_gemma":0.0004760327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009072626,"about_ca_topic_score_gemma":0.00818127,"domain_scores_codex":[0.9962425,0.001815133,0.0004959689,0.0003098297,0.0008048472,0.000331689],"domain_scores_gemma":[0.998943,0.0001206606,0.0002418377,0.0001778527,0.0003180782,0.0001986066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05344027,0.056019,0.2194321,0.000288272,0.001688965,0.000722042,0.008576286,0.00005774586,0.4504252,0.00008492426,0.006493268,0.2027719],"study_design_scores_gemma":[0.4273864,0.1054259,0.09521983,0.001444012,0.0002834493,0.006091365,0.1031846,0.002870498,0.01866791,0.0002598904,0.2376293,0.001536748],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944897,0.002296916,0.0005355352,0.001720501,0.0001420194,0.0007479942,0.00003066203,0.00000137881,0.00003531317],"genre_scores_gemma":[0.9988681,0.0005955652,0.00006187111,0.0001281112,0.0001005567,0.00007852586,0.0000213593,0.00002122604,0.00012465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4317573,"threshold_uncertainty_score":0.4884863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566007790244903,"score_gpt":0.4366595065627358,"score_spread":0.4009994286602868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}