{"id":"W4206125469","doi":"10.2196/32234","title":"Microbial Ecosystem Therapeutic-2 Intervention in People With Major Depressive Disorder and Generalized Anxiety Disorder: Phase 1, Open-Label Study","year":2022,"lang":"en","type":"article","venue":"Interactive Journal of Medical Research","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Providence Health Care","funders":"Mitacs","keywords":"Tolerability; Generalized anxiety disorder; Anxiety; Major depressive disorder; Adverse effect; Microbiome; Medicine; Internal medicine; Rating scale; Depression (economics); Psychiatry; Psychology; Bioinformatics; Mood; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001825131,0.001284791,0.002379854,0.0004514141,0.0005416759,0.0006632329,0.0007016961,0.001480173,0.004422053],"category_scores_gemma":[0.0009434331,0.0006001279,0.001613113,0.0003177544,0.0007408815,0.0007045722,0.0004856891,0.001867876,0.000588744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005735926,"about_ca_system_score_gemma":0.001302321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007847359,"about_ca_topic_score_gemma":0.002704667,"domain_scores_codex":[0.9993518,0.0003125916,0.00003944738,0.00009305782,0.00006907337,0.0001340138],"domain_scores_gemma":[0.9994898,0.00009234304,0.0001311981,0.00005252804,0.00005735307,0.0001767856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7687414,0.140608,0.003606856,0.002142109,0.00162071,0.0001314726,0.0002419606,0.0004802212,0.01847653,0.0001315529,0.001458353,0.06236085],"study_design_scores_gemma":[0.6183136,0.3725501,0.006541348,0.00005095478,0.0003968512,0.00004947092,0.00004499214,0.000264521,0.0007945835,0.00008797129,0.0008907943,0.00001482026],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842626,0.002696961,0.0007203693,0.000380151,0.0001800343,0.009720401,0.001015966,0.00007706681,0.0009465333],"genre_scores_gemma":[0.9676012,0.003375509,0.004312871,0.001359918,0.0004886583,0.01939422,0.001085976,0.00001729566,0.00236434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004422053,"threshold_uncertainty_score":0.01479322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566007790244903,"score_gpt":0.4366595065627358,"score_spread":0.4009994286602868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}