{"id":"W4206129249","doi":"10.1101/2022.01.17.22269397","title":"EXTRACELLULAR MATRIX REMODELING IN ATOPIC DERMATITIS HARNESSES THE ONSET OF AN ASTHMATIC PHENOTYPE AND IS A POTENTIAL CONTRIBUTOR TO THE ATOPIC MARCH","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Studienstiftung des Deutschen Volkes; Deutsche Forschungsgemeinschaft; BC Children's Hospital","keywords":"Atopic dermatitis; Immunology; Extracellular matrix; Crosstalk; Asthma; Fibronectin; Phenotype; Medicine; Biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000157517,0.0002256434,0.0001930346,0.0002692054,0.0001476721,0.0004352985,0.00009424047,0.0002852279,0.00110619],"category_scores_gemma":[0.00009678047,0.0001059518,0.0002321154,0.0001588886,0.0001994013,0.0001964007,0.0002526895,0.0005445116,0.000206821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001642074,"about_ca_system_score_gemma":0.0001307692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000167534,"about_ca_topic_score_gemma":0.0002696141,"domain_scores_codex":[0.9998616,0.00002957649,0.00001200902,0.00002690906,0.00003542057,0.00003451384],"domain_scores_gemma":[0.9999126,0.000008322084,0.00003309408,0.000008466983,0.00001104069,0.00002634155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002450834,0.00007182625,0.006292287,0.0001223921,0.00002176616,0.0006229801,0.00004704187,0.00004285769,0.9881191,0.0002595968,0.0001308694,0.004024182],"study_design_scores_gemma":[0.00006745589,0.001815294,0.434918,0.0001556765,0.0002244903,0.009801328,0.0009535399,0.00262293,0.5312782,0.001709622,0.01642301,0.00003036134],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897559,0.006554623,0.001384644,0.0002186395,0.00006305644,0.00003842462,0.0002400254,0.00004013508,0.001704556],"genre_scores_gemma":[0.9960451,0.001906796,0.0005880435,0.00009116124,0.00002956988,0.00002299521,0.000151762,0.000005036571,0.001159477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00110619,"threshold_uncertainty_score":0.003700614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598347527936636,"score_gpt":0.2913441019110553,"score_spread":0.2753606266316889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}