{"id":"W4206131181","doi":"10.1093/stmcls/sxab022","title":"Lactate Enhances Mouse ES Cell Differentiation Toward XEN Cells In Vitro","year":2022,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Endoderm; Cell biology; Embryonic stem cell; Induced pluripotent stem cell; Cellular differentiation; Reprogramming; Embryoid body; Germ layer; Epiblast; Stem cell; In vitro; Cell; Embryo; Embryogenesis; Biochemistry; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002896978,0.0004346123,0.0002554583,0.0002667984,0.0001006238,0.0002975216,0.0001868212,0.0002200866,0.001565001],"category_scores_gemma":[0.0001224285,0.0001373341,0.000329758,0.0001630517,0.0001366573,0.0002096695,0.000312039,0.0006075977,0.0006265118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809691,"about_ca_system_score_gemma":0.0001745385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007051713,"about_ca_topic_score_gemma":0.001322474,"domain_scores_codex":[0.9998197,0.00003635556,0.00003180953,0.00003900561,0.00004958045,0.00002361514],"domain_scores_gemma":[0.9998549,0.00003573063,0.00002890284,0.00002181118,0.00002297003,0.00003561347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009454598,0.00002253183,0.0001200397,0.00002830802,0.000003030057,0.00003899531,0.00002393757,0.00007034019,0.9982877,0.00009659102,0.00003696582,0.001177116],"study_design_scores_gemma":[0.000008129318,0.0001963603,0.001153806,0.0000063391,0.00001070794,0.00007882223,0.00001274655,0.0005009133,0.9950325,0.00003496525,0.002962127,0.00000244095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729421,0.004030827,0.01074328,0.0002250138,0.0001295744,0.00007122976,0.001873472,0.0002431444,0.009741452],"genre_scores_gemma":[0.9730062,0.002335687,0.008277369,0.0001535663,0.0000269116,0.00005330449,0.001988936,0.0001183204,0.01403972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001565001,"threshold_uncertainty_score":0.005235493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195187242836625,"score_gpt":0.2354903572433047,"score_spread":0.2235384848149384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}