{"id":"W4206131181","doi":"10.1093/stmcls/sxab022","title":"Lactate Enhances Mouse ES Cell Differentiation Toward XEN Cells In Vitro","year":2022,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Endoderm; Cell biology; Embryonic stem cell; Induced pluripotent stem cell; Cellular differentiation; Reprogramming; Embryoid body; Germ layer; Epiblast; Stem cell; In vitro; Cell; Embryo; Embryogenesis; Biochemistry; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003254726,0.0002097472,0.0002147704,0.0001299784,0.0001313484,0.00004592814,0.000457625,0.00009143208,0.0001670721],"category_scores_gemma":[0.000002755952,0.0002183139,0.000115558,0.0001827288,0.00004239346,0.00000761177,0.0004939255,0.0002408554,0.00009402883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007831249,"about_ca_system_score_gemma":0.00008246875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004958868,"about_ca_topic_score_gemma":0.00001658663,"domain_scores_codex":[0.9979205,0.0003075274,0.0003083388,0.0005490011,0.0004205732,0.0004941088],"domain_scores_gemma":[0.9993146,0.00002706701,0.0001221758,0.0003909693,0.00004220318,0.0001029777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001965808,0.0001809485,0.0001396885,0.00007438828,0.00001804816,0.00001325536,0.0001859527,0.0005653863,0.9965063,0.000002020908,0.001467936,0.0006494519],"study_design_scores_gemma":[0.0006442274,0.0001764487,0.00008405231,0.000003295131,0.000007634841,0.000001668882,0.0003918805,0.0003138916,0.9817009,0.000007768889,0.0164279,0.0002403207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966246,0.0005641453,0.0002036223,0.00007584679,0.0003453555,0.0004197498,0.0001592562,0.00002064982,0.001586783],"genre_scores_gemma":[0.9835904,0.0003440663,0.0001102873,0.00008917395,0.00008001502,0.0001069536,0.0001833822,0.00003969404,0.01545605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01495996,"threshold_uncertainty_score":0.8902582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195187242836625,"score_gpt":0.2354903572433047,"score_spread":0.2235384848149384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}