{"id":"W4206132389","doi":"10.1016/j.ijrobp.2021.12.166","title":"A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors","year":2022,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Testicular diseases and treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute","keywords":"Medicine; Radiation therapy; Germ cell tumors; Chemotherapy; Induction chemotherapy; Germ cell; Internal medicine; Central nervous system; Oncology; Nuclear medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002424813,0.00176143,0.002354437,0.0007632195,0.0006063557,0.001001463,0.001100153,0.001613494,0.004150357],"category_scores_gemma":[0.001327426,0.0005441668,0.001774804,0.0006509111,0.001571632,0.001063812,0.0005763263,0.003631784,0.000770102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009945882,"about_ca_system_score_gemma":0.001474722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001744626,"about_ca_topic_score_gemma":0.00262501,"domain_scores_codex":[0.9991357,0.0004302795,0.00002961935,0.0001931212,0.00006479012,0.0001464677],"domain_scores_gemma":[0.9989455,0.0002380556,0.0001659325,0.0001622672,0.00005779599,0.0004305738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7677168,0.08513372,0.009633246,0.0004464577,0.0011306,0.0001659644,0.0006675787,0.008455041,0.04249348,0.0003856096,0.001783401,0.08198806],"study_design_scores_gemma":[0.3435529,0.6314334,0.01620568,0.00001955261,0.0003871315,0.0001905264,0.0001150049,0.002344915,0.003968864,0.0003504138,0.001390243,0.00004142549],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957769,0.0004744459,0.0007654157,0.0001995665,0.00006290727,0.001249089,0.00061141,0.00007517399,0.000784987],"genre_scores_gemma":[0.9887357,0.0005068115,0.003387847,0.0005357174,0.0001028557,0.002510459,0.001936397,0.0001170369,0.002167067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004150357,"threshold_uncertainty_score":0.01388437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458802429791152,"score_gpt":0.3168108959162702,"score_spread":0.3022228716183587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}